Bacterial small RNA regulators: versatile roles and rapidly evolving variations

S Gottesman, G Storz - Cold Spring Harbor perspectives …, 2011 - cshperspectives.cshlp.org
Small RNA regulators (sRNAs) have been identified in a wide range of bacteria and found to
play critical regulatory roles in many processes. The major families of sRNAs include true …

Regulation of bacterial virulence by Csr (Rsm) systems

CA Vakulskas, AH Potts, P Babitzke… - Microbiology and …, 2015 - Am Soc Microbiol
Most bacterial pathogens have the remarkable ability to flourish in the external environment
and in specialized host niches. This ability requires their metabolism, physiology, and …

Gac/Rsm signal transduction pathway of γ‐proteobacteria: from RNA recognition to regulation of social behaviour

K Lapouge, M Schubert, FHT Allain… - Molecular …, 2008 - Wiley Online Library
In many γ‐proteobacteria, the conserved GacS/GacA (BarA/UvrY) two‐component system
positively controls the expression of one to five genes specifying small RNAs (sRNAs) that …

The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory …

A Brencic, KA McFarland, HR McManus… - Molecular …, 2009 - Wiley Online Library
We report here the results of an analysis of the regulatory range of the GacS/GacA two‐
component system in Pseudomonas aeruginosa. Using microarrays, we identified a large …

CsrB sRNA family: sequestration of RNA-binding regulatory proteins

P Babitzke, T Romeo - Current opinion in microbiology, 2007 - Elsevier
Noncoding regulatory RNA molecules, also known as small RNAs, participate in several
bacterial regulatory networks. The central component of the carbon storage regulator (Csr) …

Post‐transcriptional regulation on a global scale: form and function of Csr/Rsm systems

T Romeo, CA Vakulskas… - Environmental …, 2013 - Wiley Online Library
Originally described as a repressor of gene expression in the stationary phase of growth,
CsrA (RsmA) regulates primary and secondary metabolic pathways, biofilm formation …

RNA-binding proteins involved in post-transcriptional regulation in bacteria

E Van Assche, S Van Puyvelde… - Frontiers in …, 2015 - frontiersin.org
Post-transcriptional regulation is a very important mechanism to control gene expression in
changing environments. In the past decade, a lot of interest has been directed toward the …

The Life Cycle of L. pneumophila: Cellular Differentiation Is Linked to Virulence and Metabolism

G Oliva, T Sahr, C Buchrieser - Frontiers in cellular and infection …, 2018 - frontiersin.org
Legionella pneumophila is a gram-negative bacterium that inhabits freshwater ecosystems,
where it is present in biofilm or as planktonic form. L. pneumophila is mainly found …

Post-transcriptional global regulation by CsrA in bacteria

J Timmermans, L Van Melderen - Cellular and molecular life sciences, 2010 - Springer
Global regulation allows bacteria to rapidly modulate the expression of a large variety of
unrelated genes in response to environmental changes. Global regulators act at different …

Small noncoding RNAs controlling pathogenesis

A Toledo-Arana, F Repoila, P Cossart - Current opinion in microbiology, 2007 - Elsevier
Infectious diseases are a leading cause of mortality worldwide. A major challenge in
achieving their eradication is a better understanding of bacterial pathogenesis processes …