[HTML][HTML] Corneal endothelial dysfunction: Evolving understanding and treatment options

MO Price, JS Mehta, UV Jurkunas… - Progress in retinal and eye …, 2021 - Elsevier
The cornea is exquisitely designed to protect the eye while transmitting and focusing
incoming light. Precise control of corneal hydration by the endothelial cell layer that lines the …

Fuchs endothelial corneal dystrophy: The vicious cycle of Fuchs pathogenesis

SO Tone, V Kocaba, M Böhm, A Wylegala… - Progress in Retinal and …, 2021 - Elsevier
Fuchs endothelial corneal dystrophy (FECD) is the most common primary corneal
endothelial dystrophy and the leading indication for corneal transplantation worldwide …

[HTML][HTML] Approaches for corneal endothelium regenerative medicine

P Catala, G Thuret, H Skottman, JS Mehta… - Progress in retinal and …, 2022 - Elsevier
The state of the art therapy for treating corneal endothelial disease is transplantation.
Advances in the reproducibility and accessibility of surgical techniques are increasing the …

Fuchs endothelial corneal dystrophy: clinical, genetic, pathophysiologic, and therapeutic aspects

M Matthaei, A Hribek, T Clahsen… - Annual review of …, 2019 - annualreviews.org
Fuchs endothelial corneal dystrophy (FECD) is a bilateral corneal endothelial disorder and
the most common cause of corneal transplantation worldwide. Professor Ernst Fuchs …

[HTML][HTML] Gene therapy in the anterior eye segment

C Amador, R Shah, S Ghiam, AA Kramerov… - Current gene …, 2022 - ncbi.nlm.nih.gov
This review provides comprehensive information about the advances in gene therapy in the
anterior segment of the eye, including cornea, conjunctiva, lacrimal gland, and trabecular …

[HTML][HTML] TCF4-mediated Fuchs endothelial corneal dystrophy: Insights into a common trinucleotide repeat-associated disease

MP Fautsch, ED Wieben, KH Baratz… - Progress in retinal and …, 2021 - Elsevier
Fuchs endothelial corneal dystrophy (FECD) is a common cause for heritable visual loss in
the elderly. Since the first description of an association between FECD and common …

[HTML][HTML] Current understanding of the pathogenesis of Fuchs' endothelial corneal dystrophy

GG Nanda, DP Alone - Molecular vision, 2019 - ncbi.nlm.nih.gov
Fuchs' endothelial corneal dystrophy (FECD) is the most prominent reason for corneal-
endothelial transplantations across the globe. The disease pathophysiology manifests …

Biomaterials for corneal endothelial cell culture and tissue engineering

M Parekh, V Romano, K Hassanin… - Journal of Tissue …, 2021 - journals.sagepub.com
The corneal endothelium is the posterior monolayer of cells that are responsible for
maintaining overall transparency of the avascular corneal tissue via pump function. These …

RNA-based therapies in inherited retinal diseases

A Girach, I Audo, DG Birch… - Therapeutic …, 2022 - journals.sagepub.com
Inherited retinal diseases (IRDs) are a genetically and phenotypically heterogeneous group
of genetic eye disorders. There are more than 300 disease entities, and together this group …

Corneal gene therapy: structural and mechanistic understanding

R Kumar, NR Sinha, RR Mohan - The Ocular Surface, 2023 - Elsevier
Cornea, a dome-shaped and transparent front part of the eye, affords 2/3rd refraction and
barrier functions. Globally, corneal diseases are the leading cause of vision impairment …