Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges

LJ Millar, L Shi, A Hoerder-Suabedissen… - Frontiers in cellular …, 2017 - frontiersin.org
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Mechanisms, challenges and opportunities in stroke

EH Lo, T Dalkara, MA Moskowitz - Nature reviews neuroscience, 2003 - nature.com
Over the past two decades, research has heavily emphasized basic mechanisms that
irreversibly damage brain cells after stroke. Much attention has focused on what makes …

[HTML][HTML] Serpins promote cancer cell survival and vascular co-option in brain metastasis

M Valiente, AC Obenauf, X Jin, Q Chen, XHF Zhang… - Cell, 2014 - cell.com
Brain metastasis is an ominous complication of cancer, yet most cancer cells that infiltrate
the brain die of unknown causes. Here, we identify plasmin from the reactive brain stroma as …

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins

GA Silverman, PI Bird, RW Carrell, FC Church… - Journal of Biological …, 2001 - ASBMB
The serpins (serine proteinase inhibitors) are a superfamily of proteins (350–500 amino
acids in size) that fold into a conserved structure and employ a unique suicide substrate-like …

Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets

JY Kim, M Kawabori, MA Yenari - Current medicinal chemistry, 2014 - ingentaconnect.com
Stroke is a frequent cause of long-term disability and death worldwide. Ischemic stroke is
more commonly encountered compared to hemorrhagic stroke, and leads to tissue death by …

Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor–related protein

M Yepes, M Sandkvist, EG Moore… - The Journal of …, 2003 - Am Soc Clin Investig
The regulation of cerebrovascular permeability is critical for normal brain homeostasis, and
the “breakdown” of the blood-brain barrier (BBB) is associated with the development of …

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

EJ Su, L Fredriksson, M Geyer, E Folestad, J Cale… - Nature medicine, 2008 - nature.com
Thrombolytic treatment of ischemic stroke with tissue plasminogen activator (tPA) is
markedly limited owing to concerns about hemorrhagic complications and the requirement …

[HTML][HTML] Emerging roles of microRNAs in ischemic stroke: as possible therapeutic agents

SE Khoshnam, W Winlow, Y Farbood… - Journal of …, 2017 - ncbi.nlm.nih.gov
Stroke is one of the leading causes of death and physical disability worldwide. The
consequences of stroke injuries are profound and persistent, causing in considerable …

Pathophysiogenesis of mesial temporal lobe epilepsy: is prevention of damage antiepileptogenic?

G Curia, C Lucchi, J Vinet, F Gualtieri… - Current medicinal …, 2014 - ingentaconnect.com
Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis, possibly
caused by a primary brain injury that occurred a long time before the appearance of …

Molecular insights and therapeutic targets for blood–brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen …

R Jin, G Yang, G Li - Neurobiology of disease, 2010 - Elsevier
Blood–brain barrier (BBB) disruption, mediated through matrix metalloproteinases (MMPs)
and other mechanisms, is a critical event during ischemic stroke. Tissue plasminogen …