Summary Introduction Matrix metalloproteinases (MMPs) and 'aggrecanase'a disintegrin
and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play …

Angiogenesis, the growth of new blood vessels, is essential in the pathogenesis of joint
inflammatory disorders such as rheumatoid arthritis (RA) and osteoarthritis (OA), facilitating …

Proteolytic cleavage represents a unique and irreversible posttranslational event regulating
the function and half-life of many intracellular and extracellular proteins. The …

Generating inhibitors for AD isintegrin A nd M etalloproteinase 10 (ADAM10), a zinc-
dependent protease, was heavily invested in by the pharmaceutical industry starting over 20 …

The 'A Disintegrin And Metalloproteinase 10'(ADAM10) has gained considerable attention
due to its discovery as an 'α‐secretase'involved in the nonamyloidogenic processing of the …

Secreted frizzled-related protein 1 (SFRP1) is a member of secretory glycoprotein SFRP
family. As a primitive gene regulating cell growth, development and transformation, SFRP1 …

Notch ligands and receptors, including JAG1/2, DLL1/4, and Notch1/3, are enriched on
macrophages (MΦs), fibroblast‐like synoviocytes (FLS), and/or endothelial cells in …

The transmembrane chemokine pathways CXCL16/CXCR6 and CX3CL1/CX3CR1 are
strongly implicated in inflammation and angiogenesis. We investigated the involvement of …

Angiogenesis is an important phenomenon in the pathogenesis of some diseases, such as
numerous types of tumors and autoimmunity, and also a number of soluble and cell‐bound …

Human CD137 (4-1BB), a member of the TNF receptor family, and its ligand CD137L (4-
1BBL), are expressed on immune cells and tumor cells. CD137/CD137L interaction …