The molecular and cellular basis of pathogenesis in melioidosis: how does Burkholderia pseudomallei cause disease?

NR Lazar Adler, B Govan, M Cullinane… - FEMS microbiology …, 2009 - academic.oup.com
Melioidosis, a febrile illness with disease states ranging from acute pneumonia or
septicaemia to chronic abscesses, was first documented by). The causative agent …

Development of Burkholderia mallei and pseudomallei vaccines

EB Silva, SW Dow - Frontiers in cellular and infection microbiology, 2013 - frontiersin.org
Burkholderia mallei and Burkholderia pseudomallei are Gram-negative bacteria that cause
glanders and melioidosis, respectively. Inhalational infection with either organism can result …

A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens

PL Felgner, MA Kayala, A Vigil… - Proceedings of the …, 2009 - National Acad Sciences
Understanding the way in which the immune system responds to infection is central to the
development of vaccines and many diagnostics. To provide insight into this area, we …

A naturally derived outer-membrane vesicle vaccine protects against lethal pulmonary Burkholderia pseudomallei infection

W Nieves, S Asakrah, O Qazi, KA Brown, J Kurtz… - Vaccine, 2011 - Elsevier
Burkholderia pseudomallei, and other members of the Burkholderia, are among the most
antibiotic-resistant bacterial species encountered in human infection. Mortality rates …

A Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4A

A Cruz-Migoni, GM Hautbergue, PJ Artymiuk, PJ Baker… - Science, 2011 - science.org
The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei,
reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that …

Use of reverse vaccinology in the design and construction of nanoglycoconjugate vaccines against Burkholderia pseudomallei

LA Muruato, D Tapia, CL Hatcher, M Kalita… - Clinical and Vaccine …, 2017 - Am Soc Microbiol
Burkholderia pseudomallei is a Gram-negative, facultative intracellular pathogen that
causes the disease melioidosis in humans and other mammals. Respiratory infection with B …

Immunospecific Responses to Bacterial Elongation Factor Tu during Burkholderia Infection and Immunization

W Nieves, J Heang, S Asakrah, K Höner zu Bentrup… - PloS one, 2010 - journals.plos.org
Burkholderia pseudomallei is the etiological agent of melioidosis, a disease endemic in
parts of Southeast Asia and Northern Australia. Currently there is no licensed vaccine …

Immunodominant Francisella tularensis antigens identified using proteome microarray. ©Crown Copyright 2007 Dstl

JE Eyles, B Unal, MG Hartley, SL Newstead… - …, 2007 - Wiley Online Library
Stimulation of protective immune responses against intracellular pathogens is difficult to
achieve using non‐replicating vaccines. BALB/c mice immunized by intramuscular injection …

Immunization and Immunotherapy Approaches against Pseudomonas aeruginosa and Burkholderia cepacia Complex Infections

SA Sousa, AMM Seixas, JMM Marques, JH Leitão - Vaccines, 2021 - mdpi.com
Human infections caused by the opportunist pathogens Burkholderia cepacia complex and
Pseudomonas aeruginosa are of particular concern due to their severity, their multiple …

Novel multi-component vaccine approaches for Burkholderia pseudomallei

L Morici, AG Torres, RW Titball - Clinical & Experimental …, 2019 - academic.oup.com
Burkholderia pseudomallei is the causative agent of melioidosis. Historically believed to be
a relatively rare human disease in tropical countries, a recent study estimated that …