The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …

Cellular senescence describes an irreversible growth arrest characterized by distinct
morphology, gene expression pattern, and secretory phenotype. The final or intermediate …

Background Postoperative progression and chemotherapy resistance is the major cause of
treatment failure in patients with triple-negative breast cancer (TNBC). Currently, there is a …

Dormancy occurs when cells remain viable but stop proliferating. When most of a cancer
population undergoes this phenomenon, the result is called tumor dormancy, and when a …

The progression of proteinuric kidney diseases is associated with podocyte loss, but the
mechanisms underlying this process remain unclear. Podocytes reenter the cell cycle to …

Tumors often respond favorably to initial chemotherapy but eventually relapse with drug
resistance and increased metastatic potential. Cellular senescence is a major therapeutic …

Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In …

CBX4, a component of polycomb repressive complex 1 (PRC1), plays important roles in the
maintenance of cell identity and organ development through gene silencing. However …

Mammalian chromosomes are organized in structural and functional domains of 0.1–10 Mb,
which are characterized by high self-association frequencies in the nuclear space and …

AMP-activated protein kinase (AMPK) and its yeast homolog, Snf1, are critical regulators in
the maintenance of energy metabolic balance not only stimulating energy production but …