Tubulin is the biochemical target for several clinically used anticancer drugs, including
paclitaxel and the vinca alkaloids vincristine and vinblastine. This review describes both the …

This review examines the state of the art in synthesis as it relates to the building of complex
architectures on scales sufficient to drive human drug trials. We focus on the relatively few …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

The lichen cyanobacterial symbiont Nostoc sp. ATCC 53789 and its close relative Nostoc sp.
GSV 224 are prolific producers of natural products, generating> 25 derivatives of the …

The cryptophycins are a unique family of 16‐membered macrolide antimitotic agents
isolated from the cyanobacteria Nostoc sp. Their molecular target is tubulin protein wherein …

There is growing interest within the pharmaceutical community to undertake biological
targets that involve protein− protein 1 and, in general, biomacromolecular interactions 2 (PPI …

Tubulin is the target for an ever increasing number of unusual peptides and depsipeptides
that were originally isolated from a wide variety of organisms. Since tubulin is the major …

A highly enantioselective and convergent synthesis of cryptophycin 52 (2), an exceedingly
potent cytotoxic agent, is described. Cryptophycin 52, a synthetic variant of the cryptophycin …

Microbially derived modular polyketide synthase and nonribosomal peptide synthetase
biosynthetic pathways are a rich source of novel natural products. Development of these …

A synthesis of cryptophycin 52 (2) is reported using a Sharpless asymmetric dihydroxylation
(AD) strategy to install the epoxide moiety. The high stereoselectivity of the AD reaction that …