Mucosal vaccines, sterilizing immunity, and the future of SARS-CoV-2 virulence

D Focosi, F Maggi, A Casadevall - Viruses, 2022 - mdpi.com
Sterilizing immunity after vaccination is desirable to prevent the spread of infection from
vaccinees, which can be especially dangerous in hospital settings while managing frail …

[HTML][HTML] Live and wet markets: food access versus the risk of disease emergence

MM Naguib, R Li, J Ling, D Grace, H Nguyen-Viet… - Trends in …, 2021 - cell.com
Emerging zoonotic diseases exert a significant burden on human health and have
considerable socioeconomic impact worldwide. In Asia, live animals as well as animal …

Coevolutionary theory of hosts and parasites

LJ Buckingham, B Ashby - Journal of Evolutionary Biology, 2022 - academic.oup.com
Host and parasite evolution are closely intertwined, with selection for adaptations and
counter‐adaptations forming a coevolutionary feedback loop. Coevolutionary dynamics are …

Infection burdens and virulence under heat stress: ecological and evolutionary considerations

TE Hector, ALM Gehman… - … Transactions of the …, 2023 - royalsocietypublishing.org
As a result of global change, hosts and parasites (including pathogens) are experiencing
shifts in their thermal environment. Despite the importance of heat stress tolerance for host …

Coexistence of nestedness and modularity in host–pathogen infection networks

S Valverde, B Vidiella, R Montanez, A Fraile… - Nature Ecology & …, 2020 - nature.com
The long-term coevolution of hosts and pathogens in their environment forms a complex
web of multi-scale interactions. Understanding how environmental heterogeneity affects the …

Variation among strains of Borrelia burgdorferi in host tissue abundance and lifetime transmission determine the population strain structure in nature

CB Zinck, P Raveendram Thampy… - PLoS …, 2023 - journals.plos.org
Pathogen life history theory assumes a positive relationship between pathogen load in host
tissues and pathogen transmission. Empirical evidence for this relationship is surprisingly …

The microbiota conditions a gut milieu that selects for wild-type Salmonella Typhimurium virulence

E Gül, E Bakkeren, G Salazar, Y Steiger… - PLoS …, 2023 - journals.plos.org
Salmonella Typhimurium elicits gut inflammation by the costly expression of HilD-controlled
virulence factors. This inflammation alleviates colonization resistance (CR) mediated by the …

The roles of environmental variation and parasite survival in virulence–transmission relationships

WC Turner, PL Kamath… - Royal Society …, 2021 - royalsocietypublishing.org
Disease outbreaks are a consequence of interactions among the three components of a host–
parasite system: the infectious agent, the host and the environment. While virulence and …

The three Ts of virulence evolution during zoonotic emergence

E Visher, C Evensen, S Guth, E Lai… - … of the Royal …, 2021 - royalsocietypublishing.org
There is increasing interest in the role that evolution may play in current and future
pandemics, but there is often also considerable confusion about the actual evolutionary …

Tripartite interactions: How immunity, microbiota and pathogens interact and affect pathogen virulence evolution

SAO Armitage, E Genersch, DP McMahon… - Current opinion in insect …, 2022 - Elsevier
Highlights•Tripartite interactions occur between hosts, their microbiota, and pathogens.•
Competitive and non-competitive interactions can affect pathogen virulence.•The insect …