Introduction and hypothesis This manuscript is the International Urogynecology Consultation
(IUC) on pelvic organ prolapse (POP) chapter one, committee three, on the Pathophysiology …

Pelvic organ prolapse is a vaginal protrusion of female pelvic organs. It has high prevalence
worldwide and represents a great burden to the economy. The pathophysiology of pelvic …

Objective Maternal birth trauma to the pelvic floor muscles (PFMs) is a major risk factor for
pelvic floor disorders. Modeling and imaging studies suggest that demands placed on PFMs …

While developments in gynecologic health research continue advancing, relatively few
groups specifically focus on vaginal tissue research for areas like wound healing, device …

Remodeling of vaginal extracellular matrix and smooth muscle likely plays a critical role in
reducing the risk of maternal injury during vaginal delivery by altering the mechanical …

Background Pelvic floor dysfunction (PFD) is a group of clinical conditions including stress
urinary incontinence (SUI) and pelvic organ prolapse (POP). The abnormality of collagen …

Objective To undertake a comprehensive analysis of the biochemical tissue composition
and passive biomechanical properties of ovine vagina and relate this to the histo …

Background Maternal birth trauma to the pelvic floor muscles is thought to be consequent to
mechanical demands placed on these muscles during fetal delivery that exceed muscle …

Background Birth trauma to pelvic floor muscles is a major risk factor for pelvic floor
disorders. Intramuscular extracellular matrix determines muscle stiffness, supports …

Introduction and hypothesis We aimed to summarize the knowledge on the pathogenesis of
pelvic organ prolapse (POP) generated in animal models. Methods We searched MEDLINE …