Developmental enhancers mediate on/off patterns of gene expression in specific cell types
at particular stages during metazoan embryogenesis. They typically integrate multiple …

The ArC/XylS family of prokaryotic positive transcriptional regulators includes more than 100
proteins and polypeptides derived from open reading frames translated from DNA …

We use in situ Hi-C to probe the 3D architecture of genomes, constructing haploid and
diploid maps of nine cell types. The densest, in human lymphoblastoid cells, contains 4.9 …

The rotational positioning of DNA about the histone octamer appears to be determined by
certain sequence-dependent modulations of DNA structure. To establish the detailed nature …

DNA as the genetic material is a topic of intense interest in the 21st century, with the
genomes of many organisms having been sequenced. The double helix structure …

We tested the effect of systematic destruction of all three lac operators of the chromosomal
lac operon of Escherichia coli on repression by Lac repressor. Absence of just one 'pseudo …

DNA looping is generated by a protein or complex of proteins that simultaneously binds to
two different sites on a DNA molecule. Consequently, the intervening tens to thousands of …

Gene regulation by proteins acting nearby and Page 1 NATURE VOL. 322, 21 AUGUST 1986
REVIEW ARTICLE 697 Gene regulation by proteins acting nearby and at a distance Mark …

This review covers the physiological aspects of regulation of the arabinose operon in
Escherichia coli and the physical and regulatory properties of the operon's controlling gene …

Haydon and Guest (Haydon, D. J, and Guest, JR (1991) FEMS Microbiol. Lett. 63, 291–295)
first described the helix-turn-helix GntR family of bacterial regulators. They presented them …