Current knowledge about the impact of microgravity on gene regulation

TJ Corydon, H Schulz, P Richter, SM Strauch… - Cells, 2023 - mdpi.com
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …

Epigenetic control of skeletal muscle atrophy

W Liang, F Xu, L Li, C Peng, H Sun, J Qiu… - Cellular & Molecular …, 2024 - Springer
Skeletal muscular atrophy is a complex disease involving a large number of gene
expression regulatory networks and various biological processes. Despite extensive …

Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses

K Grigorev, TM Nelson, EG Overbey, N Houerbi… - Nature …, 2024 - nature.com
The advent of civilian spaceflight challenges scientists to precisely describe the effects of
spaceflight on human physiology, particularly at the molecular and cellular level. Newer …

Mechanistic insights into alternative gene splicing in oxidative stress and tissue injury

KJ Dery, Z Wong, M Wei… - Antioxidants & redox …, 2024 - liebertpub.com
Significance: Oxidative stress (OS) and inflammation are inducers of tissue injury. Alternative
splicing (AS) is an essential regulatory step for diversifying the eukaryotic proteome. Human …

Chromosomal damage, gene expression and alternative transcription in human lymphocytes exposed to mixed ionizing radiation as encountered in space

ML Riego, PK Meher, B Brzozowska, P Akuwudike… - Scientific Reports, 2024 - nature.com
Astronauts travelling in space will be exposed to mixed beams of particle radiation and
photons. Exposure limits that correspond to defined cancer risk are calculated by multiplying …

Muscle fibre transition and transcriptional changes of horse skeletal muscles during traditional Mongolian endurance training

T Bou, W Ding, X Ren, H Liu, W Gong… - Equine Veterinary …, 2024 - Wiley Online Library
Abstract Background Traditional Mongolian endurance training is an effective way to
improve the athletic ability of the horse for endurance events and is widely used. This …

Identification of gravity‐responsive serum proteins in spaceflight mice using a quantitative proteomic approach with data‐independent acquisition mass spectrometry

Y Kimura, Y Nakai, Y Ino, T Akiyama, K Moriyama… - …, 2024 - Wiley Online Library
Physical inactivity associated with gravity unloading, such as microgravity during spaceflight
and hindlimb unloading (HU), can cause various physiological changes. In this study, we …

The Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle

A Ahn, JJ Kim, AL Slusher, JY Ying, EY Zhang… - bioRxiv, 2024 - biorxiv.org
Purpose: Alternative RNA splicing (AS) is a highly conserved post-transcriptional
mechanism, generating mRNA variants to diversify the proteome. Acute endurance exercise …

[引用][C] Milagrosa López Riego, Prabodha Kumar Meher, Beata Brzozowska 3, Pamela Akuwudike

M Bucher, U Oestreicher, L Lundholm, A Wojcik - Scientific Reports, 2024