Temperature sensation: from molecular thermosensors to neural circuits and coding principles

R Xiao, XZS Xu - Annual review of physiology, 2021 - annualreviews.org
Temperature is a universal cue and regulates many essential processes ranging from
enzymatic reactions to species migration. Due to the profound impact of temperature on …

How Caenorhabditis elegans Senses Mechanical Stress, Temperature, and Other Physical Stimuli

MB Goodman, P Sengupta - Genetics, 2019 - academic.oup.com
Caenorhabditis elegans lives in a complex habitat in which they routinely experience large
fluctuations in temperature, and encounter physical obstacles that vary in size and …

[HTML][HTML] Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module

JE Toettcher, OD Weiner, WA Lim - Cell, 2013 - cell.com
The complex, interconnected architecture of cell-signaling networks makes it challenging to
disentangle how cells process extracellular information to make decisions. We have …

Endocytosis in the axon initial segment maintains neuronal polarity

K Eichel, T Uenaka, V Belapurkar, R Lu, S Cheng… - Nature, 2022 - nature.com
Neurons are highly polarized cells that face the fundamental challenge of
compartmentalizing a vast and diverse repertoire of proteins in order to function properly …

The neural circuits and synaptic mechanisms underlying motor initiation in C. elegans

BJ Piggott, J Liu, Z Feng, SA Wescott, XZS Xu - Cell, 2011 - cell.com
C. elegans is widely used to dissect how neural circuits and genes generate behavior.
During locomotion, worms initiate backward movement to change locomotion direction …

Unveiling gating behavior in piezoionic effect: toward neuromimetic tactile sensing

S Wang, T Yang, D Zhang, Q Hua… - Advanced Materials, 2024 - Wiley Online Library
The human perception system's information processing is intricately linked to the nonlinear
response and gating effect of neurons. While piezoionics holds potential in emulating the …

Forcing open TRP channels: Mechanical gating as a unifying activation mechanism

C Liu, C Montell - Biochemical and biophysical research communications, 2015 - Elsevier
Transient receptor potential (TRP) proteins are cation channels that comprise a superfamily
of molecular sensors that enable animals to detect a wide variety of environmental stimuli …

A set of hub neurons and non-local connectivity features support global brain dynamics in C. elegans

K Uzel, S Kato, M Zimmer - Current Biology, 2022 - cell.com
The wiring architecture of neuronal networks is assumed to be a strong determinant of their
dynamical computations. An ongoing effort in neuroscience is therefore to generate …

[HTML][HTML] Squishy matters–Corneal mechanobiology in health and disease

SM Thomasy, BC Leonard, MA Greiner… - Progress in retinal and …, 2024 - Elsevier
The cornea, as a dynamic and responsive tissue, constantly interacts with mechanical forces
in order to maintain its structural integrity, barrier function, transparency and refractive …

Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C. elegans

N Cermak, SK Yu, R Clark, YC Huang, SN Baskoylu… - Elife, 2020 - elifesciences.org
Animal behaviors are commonly organized into long-lasting states that coordinately impact
the generation of diverse motor outputs such as feeding, locomotion, and grooming …