Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination
R Pecori, S Di Giorgio, J Paulo Lorenzo… - Nature Reviews …, 2022 - nature.com
The AID/APOBEC polynucleotide cytidine deaminases have historically been classified as
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …
The APOBEC protein family: united by structure, divergent in function
JD Salter, RP Bennett, HC Smith - Trends in biochemical sciences, 2016 - cell.com
The APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family of proteins
have diverse and important functions in human health and disease. These proteins have an …
have diverse and important functions in human health and disease. These proteins have an …
Six reference-quality genomes reveal evolution of bat adaptations
Bats possess extraordinary adaptations, including flight, echolocation, extreme longevity
and unique immunity. High-quality genomes are crucial for understanding the molecular …
and unique immunity. High-quality genomes are crucial for understanding the molecular …
[HTML][HTML] APOBECs and virus restriction
RS Harris, JP Dudley - Virology, 2015 - Elsevier
The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …
Evidence for APOBEC3B mutagenesis in multiple human cancers
Thousands of somatic mutations accrue in most human cancers, and their causes are
largely unknown. We recently showed that the DNA cytidine deaminase APOBEC3B …
largely unknown. We recently showed that the DNA cytidine deaminase APOBEC3B …
HIV restriction factors and mechanisms of evasion
MH Malim, PD Bieniasz - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Retroviruses have long been a fertile model for discovering host–pathogen interactions and
their associated biological principles and processes. These advances have not only …
their associated biological principles and processes. These advances have not only …
APOBEC-induced mutagenesis in cancer
TM Mertz, CD Collins, M Dennis… - Annual Review of …, 2022 - annualreviews.org
The initiation, progression, and relapse of cancers often result from mutations occurring
within somatic cells. Consequently, processes that elevate mutation rates accelerate …
within somatic cells. Consequently, processes that elevate mutation rates accelerate …
[HTML][HTML] Potential APOBEC-mediated RNA editing of the genomes of SARS-CoV-2 and other coronaviruses and its impact on their longer term evolution
J Ratcliff, P Simmonds - Virology, 2021 - Elsevier
Members of the APOBEC family of cytidine deaminases show antiviral activities in
mammalian cells through lethal editing in the genomes of small DNA viruses, herpesviruses …
mammalian cells through lethal editing in the genomes of small DNA viruses, herpesviruses …
[HTML][HTML] Evasion of host immune defenses by human papillomavirus
A majority of human papillomavirus (HPV) infections are asymptomatic and self-resolving in
the absence of medical interventions. Various innate and adaptive immune responses, as …
the absence of medical interventions. Various innate and adaptive immune responses, as …