The global epidemic of the SARS-CoV-2 delta variant, key spike mutations and immune escape

D Tian, Y Sun, J Zhou, Q Ye - Frontiers in immunology, 2021 - frontiersin.org
During the COVID-19 pandemic, SARS-CoV-2 variants have emerged and spread
worldwide. The Delta (B. 1.617. 2) variant was first reported in India in October 2020 and …

COVID‐19 in nursing homes: calming the perfect storm

JG Ouslander, DC Grabowski - Journal of the American …, 2020 - Wiley Online Library
The pandemic of viral infection with the severe acute respiratory syndrome coronavirus‐2
that causes COVID‐19 disease has put the nursing home industry in crisis. The combination …

Evaluation of the relative virulence of novel SARS-CoV-2 variants: a retrospective cohort study in Ontario, Canada

DN Fisman, AR Tuite - Cmaj, 2021 - Can Med Assoc
Background: Between February and June 2021, the initial wild-type strains of SARS-CoV-2
were supplanted in Ontario, Canada, by new variants of concern (VOCs), first those with the …

Effect of bamlanivimab vs placebo on incidence of COVID-19 among residents and staff of skilled nursing and assisted living facilities: a randomized clinical trial

MS Cohen, A Nirula, MJ Mulligan, RM Novak… - Jama, 2021 - jamanetwork.com
Importance Preventive interventions are needed to protect residents and staff of skilled
nursing and assisted living facilities from COVID-19 during outbreaks in their facilities …

Association of pre-existing comorbidities with mortality and disease severity among 167,500 individuals with COVID-19 in Canada: A population-based cohort study

E Ge, Y Li, S Wu, E Candido, X Wei - PLoS One, 2021 - journals.plos.org
Background The novel coronavirus disease 2019 (COVID-19) has infected 1.9% of the world
population by May 2, 2021. Since most previous studies that examined risk factors for …

For-profit long-term care homes and the risk of COVID-19 outbreaks and resident deaths

NM Stall, A Jones, KA Brown, PA Rochon, AP Costa - Cmaj, 2020 - Can Med Assoc
BACKGROUND: Long-term care (LTC) homes have been the epicentre of the coronavirus
disease 2019 (COVID-19) pandemic in Canada to date. Previous research shows that for …

Association between nursing home crowding and COVID-19 infection and mortality in Ontario, Canada

KA Brown, A Jones, N Daneman, AK Chan… - JAMA internal …, 2021 - jamanetwork.com
Importance Nursing home residents have been disproportionately affected by coronavirus
disease 2019 (COVID-19). Prevention recommendations emphasize frequent testing of …

Progressive increase in virulence of novel SARS-CoV-2 variants in Ontario, Canada

DN Fisman, AR Tuite - MedRxiv, 2021 - medrxiv.org
Abstract Background The period from February to June 2021 was one during which initial
wild-type SARS-CoV-2 strains were supplanted in Ontario, Canada, first by variants of …

COVID-19 in long-term care homes in Ontario and British Columbia

M Liu, CJ Maxwell, P Armstrong, M Schwandt, A Moser… - Cmaj, 2020 - Can Med Assoc
Columbia exhibited a number of potential strengths relevant to pandemic preparedness
compared with Ontario: there was better coordination between long-term care, public health …

Reduced magnitude and durability of humoral immune responses to COVID-19 mRNA vaccines among older adults

MA Brockman, F Mwimanzi, HR Lapointe… - The Journal of …, 2022 - academic.oup.com
Background The magnitude and durability of immune responses to coronavirus disease
2019 (COVID-19) mRNA vaccines remain incompletely characterized in the elderly …