Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

The control of Leishmania infection relies primarily on chemotherapy till date. Resistance to
pentavalent antimonials, which have been the recommended drugs to treat cutaneous and …

Metacaspases are cysteine-dependent proteases found in protozoa, fungi and plants and
are distantly related to metazoan caspases. Although metacaspases share structural …

Stress granules (SGs) are highly conserved cytoplasmic condensates that assemble in
response to stress and contribute to maintaining protein homeostasis. These membraneless …

The growing incidence of parasitic resistance against generic pentavalent antimonials,
specifically for visceral disease in Indian subcontinent, is a serious issue in Leishmania …

Leishmaniasis, a group of diseases caused by hemoflagellate obligate intracellular protozoa
(trypanosomatids) from the genus Leishmania, has not received the attention it deserves …

Apoptosis and other types of regulated cell death have been defined as fundamental
processes in plant and animal development, but the occurrence of, and possible roles for …

Acidocalcisomes are acidic organelles containing calcium and a high concentration of
phosphorus in the form of pyrophosphate (PPi) and polyphosphate (poly P). Organelles with …

Autophagy is a major nutrient recycling mechanism in plants. However, its functional
connection with programmed cell death (PCD) is a topic of active debate and remains not …

Electron microscopy has proven to be a reliable and essential tool to determine
morphological alterations and target organelles in the investigation of new drugs for Chagas …