A class of small, non-coding transcripts called microRNAs (miRNAs) that provide a crucial
and pervasive layer of post-transcriptional gene regulation has recently emerged and …

'The development of a multicellular organism from a single egg cell requires both the
determination of many cell types and the organization of these cells into an elaborate pattern …

During C. elegans development, the temporal pattern of many cell lineages is specified by
graded activity of the heterochronic gene Lin-14. Here we demonstrate that a temporal …

In developing organisms, spatially prescribed cell identities are thought to be determined by
the expression levels of multiple genes. Quantitative tests of this idea, however, require a …

Gap genes are involved in segment determination during the early development of the fruit
fly Drosophila melanogaster as well as in other insects. This review attempts to synthesize …

The zinc-finger protein Nanos and the RNA-binding protein Pumilio act together to repress
the translation of maternal hunchback RNA in the posterior of the Drosophila embryo …

Segmental pattern in the Drosophila embryo is established by two maternal factors localized
to the anterior and posterior poles of the egg cell. Here we provide molecular evidence that …

Anterior-posterior polarity of the Drosophila embryo is initiated during oogenesis through
differential mao ternal RNA localization. The RNA of the anterior mor· phogen bicoid is …

Planarians have been a classic model system for the study of regeneration, tissue
homeostasis, and stem cell biology for over a century, but they have not historically been …

By the 4-cell stage of C. elegans embryogenesis, a ventral blastomere, called EMS, is
already committed 'to producing pharyngeal and intestinal cell types. Recessive, maternal …