Deciphering miRNAs' action through miRNA editing

M Correia de Sousa, M Gjorgjieva, D Dolicka… - International journal of …, 2019 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNAs with the capability of modulating gene
expression at the post-transcriptional level either by inhibiting messenger RNA (mRNA) …

A-to-I RNA editing—immune protector and transcriptome diversifier

E Eisenberg, EY Levanon - Nature Reviews Genetics, 2018 - nature.com
Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …

Efficient in vitro and in vivo RNA editing via recruitment of endogenous ADARs using circular guide RNAs

D Katrekar, J Yen, Y Xiang, A Saha, D Meluzzi… - Nature …, 2022 - nature.com
Recruiting endogenous adenosine deaminases using exogenous guide RNAs to edit
cellular RNAs is a promising therapeutic strategy, but editing efficiency and durability remain …

Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo

Z Yi, L Qu, H Tang, Z Liu, Y Liu, F Tian, C Wang… - Nature …, 2022 - nature.com
Current methods for programmed RNA editing using endogenous ADAR enzymes and
engineered ADAR-recruiting RNAs (arRNAs) suffer from low efficiency and bystander off …

Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor

Q Xiao, Z Xu, Y Xue, C Xu, L Han, Y Liu… - Science Translational …, 2022 - science.org
Programmable RNA editing tools enable the reversible correction of mutant transcripts,
reducing the potential risk associated with permanent genetic changes associated with the …

Precision RNA base editing with engineered and endogenous effectors

LS Pfeiffer, T Stafforst - Nature Biotechnology, 2023 - nature.com
RNA base editing refers to the rewriting of genetic information within an intact RNA molecule
and serves various functions, such as evasion of the endogenous immune system and …

Endogenous ADAR-mediated RNA editing in non-human primates using stereopure chemically modified oligonucleotides

P Monian, C Shivalila, G Lu, M Shimizu, D Boulay… - Nature …, 2022 - nature.com
Technologies that recruit and direct the activity of endogenous RNA-editing enzymes to
specific cellular RNAs have therapeutic potential, but translating them from cell culture into …

Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs

L Qu, Z Yi, S Zhu, C Wang, Z Cao, Z Zhou, P Yuan… - Nature …, 2019 - nature.com
Current tools for targeted RNA editing rely on the delivery of exogenous proteins or
chemically modified guide RNAs, which may lead to aberrant effector activity, delivery …

RNA editing: Expanding the potential of RNA therapeutics

BJ Booth, S Nourreddine, D Katrekar, Y Savva, D Bose… - Molecular Therapy, 2023 - cell.com
RNA therapeutics have had a tremendous impact on medicine, recently exemplified by the
rapid development and deployment of mRNA vaccines to combat the COVID-19 pandemic …

Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides

T Merkle, S Merz, P Reautschnig, A Blaha, Q Li… - Nature …, 2019 - nature.com
Site-directed RNA editing might provide a safer or more effective alternative to genome
editing in certain clinical scenarios. Until now, RNA editing has relied on overexpression of …