Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

The canonical appearance of the nucleus depends on constant adaptation and remodeling
of the nuclear envelope in response to changing biomechanical forces and metabolic …

The nucleus is a mechanically stable compartment of the cell that contains the genome and
performs many essential functions. Nuclear mechanical components chromatin and lamins …

Lamina‐associated domains are large regions of heterochromatin positioned at the nuclear
periphery. These domains have been implicated in gene repression, especially in the …

High-throughput imaging (HTI) generates complex imaging datasets from a large number of
experimental perturbations. Commercial HTI software programs for image analysis …

The maintenance of nuclear shape is essential for cellular homeostasis and disruptions in
this process have been linked to various pathological conditions, including cancer …

Errors during cell division lead to aneuploidy, which is associated with genomic instability
and cell transformation. In response to aneuploidy, cells activate the tumour suppressor p53 …

Nuclear blebs are herniations of the nucleus that occur in diseased nuclei that cause
nuclear rupture leading to cellular dysfunction. Chromatin and lamins are two of the major …

The nuclear lamina (NL) is a crucial component of the inner nuclear membrane (INM) and
consists of lamin filaments and associated proteins. Lamins are type V intermediate filament …

The nuclear lamina (NL) lines the nuclear envelope (NE) to maintain nuclear structure in
metazoan cells. The major NL components, the nuclear lamins contribute to the protection …