The spectrum of focal segmental glomerulosclerosis: new insights

VD D'Agati - Current opinion in nephrology and hypertension, 2008 - journals.lww.com
The spectrum of focal segmental glomerulosclerosis: new insi... : Current Opinion in
Nephrology and Hypertension The spectrum of focal segmental glomerulosclerosis: new …

Potential role of Akt signaling in chronic kidney disease

A Lan, J Du - Nephrology Dialysis Transplantation, 2015 - academic.oup.com
Renal fibrosis, particularly tubulointerstitial fibrosis, is the common final outcome of almost
all chronic kidney diseases. However, the mechanisms involved in the development of renal …

Krüppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation

SK Mallipattu, R Liu, F Zheng, G Narla… - Journal of Biological …, 2012 - ASBMB
Podocyte injury resulting from a loss of differentiation is the hallmark of many glomerular
diseases. We previously showed that retinoic acid (RA) induces podocyte differentiation via …

Inhibition of the VEGF signalling pathway and glomerular disorders

M Ollero, D Sahali - Nephrology Dialysis Transplantation, 2015 - academic.oup.com
Anti-cancer therapeutic approaches targeting the vascular endothelial growth factor (VEGF)
ligand (anti-VEGF) or inhibiting its receptors (RTKI) have recently been developed. In spite …

Role for membrane remodeling in cell death: implication for health and disease

X Tekpli, JA Holme, O Sergent, D Lagadic-Gossmann - Toxicology, 2013 - Elsevier
Recently it has become clear that exposure to xenobiotics may result in various forms of cell
death; not only passive cell deaths like necrosis, or programmed cell deaths such as …

Podocyte repopulation contributes to regression of glomerular injury induced by ACE inhibition

D Macconi, F Sangalli, M Bonomelli, S Conti… - The American journal of …, 2009 - Elsevier
Angiotensin-converting enzyme (ACE) inhibition induces glomerular repair in the Munich
Wistar Frömter (MWF) rat, a model of spontaneous glomerular injury. In this study, we …

Repeated systemic administration of human adipose-derived stem cells attenuates overt diabetic nephropathy in rats

L Zhang, K Li, X Liu, D Li, C Luo, B Fu… - Stem Cells and …, 2013 - liebertpub.com
Adipose-derived stem cells (ASCs) can alleviate acute kidney injury and promote kidney cell
regeneration and repair. To investigate the role of ASCs in diabetic nephropathy (DN) …

Cells of renin lineage are adult pluripotent progenitors in experimental glomerular disease

JW Pippin, NV Kaverina, DG Eng… - American Journal …, 2015 - journals.physiology.org
Modified vascular smooth muscle cells of the kidney afferent arterioles have recently been
shown to serve as progenitors for glomerular epithelial cells in response to glomerular …

Signaling in regulation of podocyte phenotypes

PY Chuang, JC He - Nephron Physiology, 2009 - karger.com
The kidney podocyte is a terminally differentiated and highly specialized cell. The function of
the glomerular filtration barrier depends on the integrity of the podocyte. Podocyte injury and …

Membranous nephropathy

AV Cybulsky - Experimental Models for Renal Diseases, 2011 - karger.com
The understanding of cellular and molecular mechanisms involved in the pathogenesis of
membranous nephropathy (MN) has come from studies carried out in the Heymann nephritis …