Shortening synthetic routes to small molecule active pharmaceutical ingredients employing biocatalytic methods

S Simić, E Zukić, L Schmermund, K Faber… - Chemical …, 2021 - ACS Publications
Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Power of biocatalysis for organic synthesis

CK Winkler, JH Schrittwieser, W Kroutil - ACS central science, 2021 - ACS Publications
Biocatalysis, using defined enzymes for organic transformations, has become a common
tool in organic synthesis, which is also frequently applied in industry. The generally high …

Stereodynamic strategies to induce and enrich chirality of atropisomers at a late stage

CB Roos, CH Chiang, LAM Murray, D Yang… - Chemical …, 2023 - ACS Publications
Enantiomers, where chirality arises from restricted rotation around a single bond, are
atropisomers. Due to the unique nature of the origins of their chirality, synthetic strategies to …

Enantioconvergent transformations of secondary alcohols through borrowing hydrogen catalysis

Y Gao, G Hong, BM Yang, Y Zhao - Chemical Society Reviews, 2023 - pubs.rsc.org
Direct substitution of readily available alcohols is recognized as a key research area in
green chemical synthesis. Starting from simple racemic secondary alcohols, the …

Enantioselective C(sp3)‒H bond activation by chiral transition metal catalysts

TG Saint-Denis, RY Zhu, G Chen, QF Wu, JQ Yu - Science, 2018 - science.org
BACKGROUND The ultimate goal of synthetic chemistry is the efficient assembly of
molecules from readily available starting materials with minimal waste generation. The …

Combinations of aminocatalysts and metal catalysts: a powerful cooperative approach in selective organic synthesis

S Afewerki, A Cordova - Chemical reviews, 2016 - ACS Publications
The cooperation and interplay between organic and metal catalyst systems is of utmost
importance in nature and chemical synthesis. Here innovative and selective cooperative …

Cobalt (III)/Chiral Carboxylic Acid‐Catalyzed Enantioselective Synthesis of Benzothiadiazine‐1‐oxides via C− H Activation

Y Hirata, D Sekine, Y Kato, L Lin… - Angewandte Chemie …, 2022 - Wiley Online Library
Among sulfoximine derivatives containing a chiral sulfur center, benzothiadiazine‐1‐oxides
are important for applications in medicinal chemistry. Here, we report that the combination of …

Enzyme immobilization: the quest for optimum performance

RA Sheldon - Advanced Synthesis & Catalysis, 2007 - Wiley Online Library
Immobilization is often the key to optimizing the operational performance of an enzyme in
industrial processes, particularly for use in non‐aqueous media. Different methods for the …

[引用][C] Green Chemistry and Catalysis

RA Sheldon - 2007 - books.google.com
This first book to focus on catalytic processes from the viewpoint of green chemistry presents
every important aspect:? Numerous catalytic reductions and oxidations methods? Solid-acid …

Industrial methods for the production of optically active intermediates

M Breuer, K Ditrich, T Habicher, B Hauer… - Angewandte Chemie …, 2004 - Wiley Online Library
Enantiomerically pure amino acids, amino alcohols, amines, alcohols, and epoxides play an
increasingly important role as intermediates in the pharmaceutical industry and …