Microglia are the resident innate immune cells of the central nervous system that mediate
brain homeostasis maintenance. Microglia-mediated neuroinflammation is a hallmark …

The abundance of intrinsic disorder in the protein realm and its role in a variety of
physiological and pathological cellular events have strengthened the interest of the scientific …

The functional amyloid state of proteins has in recent years garnered much attention for its
role in serving crucial and diverse biological roles. Amyloid is a protein fold characterised by …

Prions are self‐perpetuating proteins able to switch between a soluble state and an
aggregated‐and‐transmissible conformation. These proteinaceous entities have been …

Prions are a singular subset of proteins able to switch between a soluble conformation and a
self-perpetuating amyloid state. Traditionally associated with neurodegenerative diseases …

Reports on phase separation and amyloid formation for multiple proteins and aggregation-
prone peptides are recurrently used to explore the molecular mechanisms associated with …

Prion-like behaviour is attracting much attention due to the growing evidences that amyloid-
like self-assembly may reach beyond neurodegeneration and be a conserved functional …

A disordered to β-sheet transition was thought to drive the functional switch of Q/N-rich
prions, similar to pathogenic amyloids. However, recent evidence indicates a critical role for …

Prion-like domains (PrLDs) are intrinsically disordered regions (IDRs) of low sequence
complexity with a similar composition to yeast prion domains. PrLDs-containing proteins …

Several databases collecting amyloidogenic regions have been released to provide
information on protein sequences able to form amyloid fibrils. However, most of these …