During animal development, cell-fate-specific changes in gene expression can modify the
material properties of a tissue and drive tissue morphogenesis. While mechanistic insights …

Epithelial–mesenchymal transitions (EMTs) are an important mechanism for reorganizing
germ layers and tissues during embryonic development. They have both a morphogenic …

Oriented cell division is an integral part of pattern development in processes ranging from
asymmetric segregation of cell-fate determinants to the shaping of tissues,. Despite …

The correlation between cell shape elongation and the orientation of the division axis
described by early cell biologists is still used as a paradigm in developmental studies …

Background: The morphogenetic events of early vertebrate development generally involve
the combined actions of several populations of cells, each engaged in a distinct behavior …

The establishment and maintenance of epithelial cell-cell junctions is crucially important to
regulate adhesion, apico-basal polarity and motility of epithelial cells, and ultimately controls …

Generation of inside cells that develop into inner cell mass (ICM) and outside cells that
develop into trophectoderm is central to the development of the early mouse embryo. Critical …

Short-period (ultradian) oscillations of Hes1, a Notch signaling effector, are essential for
maintaining neural progenitors in a proliferative state, while constitutive downregulation of …

Cell division orientation during animal development can serve to correctly organize and
shape tissues, create cellular diversity or both. The underlying cellular mechanism is …

Gastrulation is a developmental process to generate the mesoderm and endoderm from the
ectoderm, of which the epithelial to mesenchymal transition (EMT) is generally considered to …