BACKGROUND A gap exists between in vivo and ex vivo coagulation when investigated by
use of the coagulation tests prothrombin time (PT) and activated partial thromboplastin time …

Determining patient's coagulation profile, ie detecting a bleeding tendency or the opposite, a
thrombotic risk, is crucial for clinicians in many situations. Routine coagulation assays and …

The management of perioperative bleeding involves multiple assessments and strategies to
ensure appropriate patient care. Initially, it is important to identify those patients with an …

1School of Medicine, Cardiff University, University Hospital of Wales, Wales, 2Royal
Hospital for Sick Children, Glasgow, 3The London School of Medicine and Dentistry, Royal …

Hemophilia is a bleeding disorder caused by deficiency in factors VIII or IX, the two
components of the intrinsic Xase complex. Treatment with replacement factor can lead to the …

Maintaining normal hemostasis relies on a regulated system of procoagulant and
anticoagulant pathways, and disruption of these processes leads to the loss of hemostatic …

Abstract Treatment of patients with hemophilia A and B has undergone significant advances
during the past 2 decades. However, despite these advances, the development of …

Hemophilia is a bleeding disorder that afflicts about 1 in 5000 males. Treatment relies upon
replacement of the deficient factor, and response to treatment both in clinical research and …

The treatment of hemophilia consists of clotting factor replacement to prevent and control
bleeding. The development of an inhibitor is one of the most serious complications of the …

The serine protease thrombin, a naturally derived enzyme, plays a key role in hemostasis by
converting fibrinogen to fibrin and activating coagulation factor XIII whereby the fibrin clot is …