Oropharyngeal carcinoma with a special focus on HPV-related squamous cell carcinoma

RL Ferris, W Westra - Annual Review of Pathology: Mechanisms …, 2023 - annualreviews.org
Human papillomavirus–positive oropharyngeal squamous cell carcinoma (HPV-OPSCC)
has one of the most rapidly increasing incidences of any cancer in high-income countries …

Clinical, morphologic and molecular heterogeneity of HPV-associated oropharyngeal cancer

YX Lim, ML Mierzwa, MA Sartor, NJ D'Silva - Oncogene, 2023 - nature.com
The incidence of human papillomavirus-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) is rising rapidly and has exceeded cervical cancer to become the most …

High-dimensional mapping of human CEACAM1 expression on immune cells and association with melanoma drug resistance

YH Huang, CH Yoon, A Gandhi, T Hanley… - Communications …, 2024 - nature.com
Background Human carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) is an
inhibitory cell surface protein that functions through homophilic and heterophilic ligand …

The drivers, mechanisms, and consequences of genome instability in HPV-driven cancers

VL Porter, MA Marra - Cancers, 2022 - mdpi.com
Simple Summary Cells infected with high-risk human papillomaviruses (HPV) can
accumulate DNA damage and eventually transform into HPV-driven cancers. Genome …

Heparan sulfate and sialic acid in viral attachment: Two sides of the same coin?

IE Ramos-Martínez, E Ramos-Martínez… - International Journal of …, 2022 - mdpi.com
Sialic acids and heparan sulfates make up the outermost part of the cell membrane and the
extracellular matrix. Both structures are characterized by being negatively charged, serving …

Tonsillar Cancer with High CD8+ T-Cell Infiltration Features Increased Levels of Dendritic Cells and Transcriptional Regulation Associated with an Inflamed Tumor …

DG Jimenez, A Sobti, D Askmyr, C Sakellariou… - Cancers, 2021 - mdpi.com
Simple Summary Human papilloma virus (HPV) infection is the leading cause of tonsillar
cancer (TC), and HPV+ TC has a favorable prognosis as compared to HPV− TC. Further …

Development of a spontaneous HPV16 E6/E7-expressing head and neck squamous cell carcinoma in HLA-A2 transgenic mice

S Peng, D Xing, L Ferrall, YC Tsai, RBS Roden… - MBio, 2022 - Am Soc Microbiol
Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma
(HNSCC) is a growing global health problem. HPV16 has been attributed to a majority of …

[HTML][HTML] The imprint of viral oncoproteins on the variable clinical behavior among human papilloma virus-related oropharyngeal squamous cell carcinomas

MK Sannigrahi, L Raghav, A Diab, D Basu - Tumour Virus Research, 2024 - Elsevier
Human papilloma virus-related (HPV+) oropharyngeal squamous cell carcinomas
(OPSCCs) are variable in their progression, immune landscape, treatment responses, and …

[HTML][HTML] Gut microbiome's causal role in head and neck cancer: findings from mendelian randomization

M Lian, M Sun, B Han, A Baranova, H Cao… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Introduction The gut microbiome (GM) has been implicated in cancer pathogenesis and
treatment, including head and neck cancers (HNC). However, the specific microbial …

Human papillomavirus oral infection: review of Methodological aspects and Epidemiology

E Giuliani, F Rollo, MG Donà, AR Garbuglia - Pathogens, 2021 - mdpi.com
Oral infection by Human Papillomavirus (HPV) has recently gained great attention because
of its involvement in the development of a subset of head and neck squamous cell …