The neurodevelopmental model of schizophrenia, which posits that the illness is the end
state of abnormal neurodevelopmental processes that started years before the illness onset …

Although schizophrenia is an illness that has been historically characterized by the
presence of positive symptomatology, decades of research highlight the importance of …

Despite an increasing number of published voxel based morphometry studies of
schizophrenia, there has been no adequate attempt to examine gray (GM) and white matter …

Many of the major neuropsychiatric illnesses, including schizophrenia, have a typical age of
onset in late adolescence. Late adolescence may reflect a critical period in brain …

In schizophrenia, brain-wide alterations have been identified at the molecular and cellular
levels, yet how these phenomena affect cortical circuit activity remains unclear. We studied …

OBJECTIVES: In early stage psychosis research the identification of neurobiological
correlates of vulnerability to schizophrenia is an important hurdle. METHODS: We …

Context Longitudinal magnetic resonance imaging studies have shown progressive gray
matter reduction in the superior temporal gyrus during the earliest phases of schizophrenia …

Background Psychotic disorders are associated with widespread reductions in white matter
(WM) integrity. However, the stage at which these abnormalities first appear and whether …

BACKGROUND: White matter microstructural disruptions have been observed in patients
with schizophrenia. However, whether changes exist prior to disease onset or in high-risk …

The introduction of clinical criteria for the operationalization of psychosis high risk provided a
basis for early detection and treatment of vulnerable individuals. However, about two-thirds …