In the contexts of aging, injury, or neuroinflammation, activated microglia signaling with TNF-
α, IL-1α, and C1q induces a neurotoxic astrocytic phenotype, classified as A1, A1-like, or …

Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

The function and regulation of different heterogeneous reactive states of astrocytes in
depression remain unclear. Here, we demonstrate that neurotoxic reactive (A1-like) …

Astrocytes play a pivotal role in maintaining the central nervous system (CNS) homeostasis
and function. In response to CNS injuries and diseases, reactive astrocytes are triggered. By …

Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome
drives release of the proinflammatory cytokines interleukin (IL)-1β and IL-18 and induces …

Pyroptosis is a type of programmed cell death characterized by cell swelling and osmotic
lysis, resulting in cytomembrane rupture and release of immunostimulatory components …

The nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-
containing protein 3 (NLRP3) inflammasome has emerged as a key mediator of pathological …

Objectives NLRP3 inflammasome is a critical part of the innate immune system and plays an
important role in a variety of inflammatory diseases. However, the effects of NLRP3 …

Neurodegenerative diseases are characterized by a dysregulated neuro-glial
microenvironment, culminating in functional deficits resulting from neuronal cell death …

Autoimmune diseases are chronic immune diseases characterized by dysregulation of
immune system, which ultimately results in a disruption in self-antigen tolerance. Cumulative …