Electrophysiology of hypokalemia and hyperkalemia

JN Weiss, Z Qu, K Shivkumar - Circulation: arrhythmia and …, 2017 - Am Heart Assoc
2 Weiss et al Potassium and Arrhythmias subthreshold EADs, thereby initiating reentry
(Figure 3, black arrows). Under these conditions, reentry can have a special property called …

[HTML][HTML] hERG K+ channels: structure, function, and clinical significance

JI Vandenberg, MD Perry, MJ Perrin… - Physiological …, 2012 - journals.physiology.org
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Cardiac ventricular repolarization reserve: a principle for understanding drug‐related proarrhythmic risk

A Varró, I Baczkó - British journal of pharmacology, 2011 - Wiley Online Library
Cardiac repolarization abnormalities can be caused by a wide range of cardiac and non‐
cardiac compounds and may lead to the development of life‐threatening Torsades de …

The human ether-a-go-go-related gene (hERG) potassium channel represents an unusual target for protease-mediated damage

SM Lamothe, J Guo, W Li, T Yang, S Zhang - Journal of Biological …, 2016 - ASBMB
The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the
rapidly activating delayed rectifier potassium channel (I Kr), which is important for cardiac …

Beta SARS-CoV-2 variant and BNT162b2 vaccine effectiveness in long-term care facilities in France

B Lefèvre, L Tondeur, Y Madec, R Grant… - The Lancet Healthy …, 2021 - thelancet.com
Variants of SARS-CoV-2 have emerged that are more transmissible than the original virus or
that exhibit some properties of immune escape, or both. The beta (B. 1.351) variant has …

The anti-addiction drug ibogaine and the heart: a delicate relation

X Koenig, K Hilber - Molecules, 2015 - mdpi.com
The plant indole alkaloid ibogaine has shown promising anti-addictive properties in animal
studies. Ibogaine is also anti-addictive in humans as the drug alleviates drug craving and …

Mechanisms of hypokalemia‐induced ventricular arrhythmogenicity

OE Osadchii - Fundamental & clinical pharmacology, 2010 - Wiley Online Library
Hypokalemia is a common biochemical finding in cardiac patients and may represent a side
effect of diuretic therapy or result from endogenous activation of renin–angiotensin system …

Dynamic of ion channel expression at the plasma membrane of cardiomyocytes

E Balse, DF Steele, H Abriel… - Physiological …, 2012 - journals.physiology.org
Cardiac myocytes are characterized by distinct structural and functional entities involved in
the generation and transmission of the action potential and the excitation-contraction …

Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to proof-of-concept in vitro studies

J Spadavecchia, D Movia, C Moore… - International journal …, 2016 - Taylor & Francis
The main objective of this study was to optimize and characterize a drug delivery carrier for
doxorubicin, intended to be intravenously administered, capable of improving the …

Molecular basis of hypokalemia-induced ventricular fibrillation

A Pezhouman, N Singh, Z Song, M Nivala… - Circulation, 2015 - Am Heart Assoc
Background—Hypokalemia is known to promote ventricular arrhythmias, especially in
combination with class III antiarrhythmic drugs like dofetilide. Here, we evaluated the …