Patients with chronic kidney disease (CKD) are at an increased risk of premature mortality,
mainly from cardiovascular causes. The association between CKD on hemodialysis and …

Understanding of vitamin D physiology is important because about half of the population is
being diagnosed with deficiency and treated with supplements. Clinical guidelines were …

Vascular calcification (VC) as a manifestation of perturbed mineral balance, is associated
with aging, diabetes and kidney dysfunction, as well as poorer patient outcomes. Due to the …

Chronic kidney disease is a devastating condition resulting from irreversible loss of nephron
numbers and function and leading to end-stage renal disease and mineral disorders …

BACKGROUND: Vascular calcification (VC) is a highly prevalent complication of chronic
kidney disease (CKD) and is associated with the higher morbidity-mortality of patients with …

Kidney fibrosis is a highly deleterious process and a final manifestation of chronic kidney
disease. Alpha-(α)-synuclein (SNCA) is an actin-binding neuronal protein with various …

The increase in prevalence and severity of vascular calcification in chronic kidney disease is
a result of complex interactions between changes in the vascular bed, mineral metabolites …

Vitamin D is necessary for bone health but may also have many extra-skeletal effects. The
vitamin D endocrine system has major effects on gene and protein expression in many cells …

We induced chronic kidney disease (CKD) with adenine in WT mice, mice with osteocyte-
specific deletion of Cyp27b1, encoding the 25-hydroxyvitamin D 1 (OH) ase [Oct-1 (OH) ase …

Objectives Recent evidence suggested that long non-coding RNAs (lncRNAs) and
microRNAs (miRNAs) play critical roles in the pathogenesis of vascular calcification (VC). In …