Clinical in vivo multiphoton FLIM tomography

K König - Methods and applications in fluorescence, 2020 - iopscience.iop.org
Abstract Fluorescence Lifetime Imaging (FLIM) in life sciences based on ultrashort laser
scanning microscopy and time-correlated single photon counting (TCSPC) started 30 years …

Two-photon imaging for non-invasive corneal examination

A Batista, P Guimarães, JP Domingues, MJ Quadrado… - Sensors, 2022 - mdpi.com
Two-photon imaging (TPI) microscopy, namely, two-photon excited fluorescence (TPEF),
fluorescence lifetime imaging (FLIM), and second-harmonic generation (SHG) modalities …

In vivo visualisation of tattoo particles using multiphoton tomography and fluorescence lifetime imaging

L Nguyen, C Mess, SW Schneider… - Experimental …, 2022 - Wiley Online Library
With increased popularity of decorative tattoos, awareness of tattoo‐based dermatological
complications has been raised. Health issues include a broad spectrum dominated by …

Skin cancer detection with a compact multimodal fiber laser multiphoton FLIM tomograph

K König, D Pankin, A Paudel, H Hänßle… - … Microscopy in the …, 2021 - spiedigitallibrary.org
A clinical multicenter study has been performed on patients with suspicious, potentially
malignant, pigmented skin lesions to evaluate the femtosecond fiber laser based compact …

Reflectance confocal microscopy of human skin using near infrared femtosecond laser pulses

A König, K König - Multiphoton Microscopy in the Biomedical …, 2022 - spiedigitallibrary.org
The optical properties of the skin including reflectance are affected by aging, dehydration,
and diseases and, therefore, can be used for non-invasive diagnosis. Multiphoton …

In vivo two-photon imaging of topically applied care cosmetics and pharmaceuticals in human skin

A König, K König - Multiphoton Microscopy in the Biomedical …, 2023 - spiedigitallibrary.org
We applied femtosecond laser multiphoton tomographs, including the novel system
MPTcompact with its chiller-free fiber laser positioned inside the measurement head, for …

history of multiphoton tomography

K König - Multiphoton Microscopy in the Biomedical Sciences …, 2023 - spiedigitallibrary.org
Two decades ago, the very first prototype of a multiphoton tomograph was built and
delivered as a high-resolution skin imaging device to the cosmetic company Beiersdorf AG …