New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

Genes | Free Full-Text | Monogenic Parkinson’s Disease: Genotype, Phenotype,
Pathophysiology, and Genetic Testing Next Article in Journal enChIP-Seq Analyzer: A …

The introduction of next generation sequencing (NGS) has led to an exponential increase of
elucidated genetic causes in both extremely rare diseases and common but heterogeneous …

An understanding of the genetic etiology of Parkinson disease (PD) has become imperative
for the modern-day neurologist. Although genetic forms cause only a minority of PD, the …

Parkinson's disease is one of the most common neurodegenerative disorders worldwide,
characterized by a progressive loss of dopaminergic neurons mainly localized in the …

Since the first description of alpha‐synuclein (SNCA) mutations in 1997, this gene has
probably become the most intensely investigated one associated with monogenic Parkinson …

Neurodegenerative diseases are a group of diseases with several neuropathological
symptoms. Degenerative nerve diseases can be serious or life‐threatening. Because of the …

Paroxonase 1 displays multiple physiological activities that position it as a putative player in
the pathogenesis of neurological disorders. Here we reviewed the literature focusing on the …

Parkinson's disease is a chronic, multifactorial and progressive neurologic condition that
affects around six million people worldwide, normally over 60 years of age, and is …

Neurodegenerative diseases affect millions of individuals worldwide. So far, no disease-
modifying drug is available to treat patients, making the search for effective drugs an urgent …