Obesity: Current and potential pharmacotherapeutics and targets

V Narayanaswami, LP Dwoskin - Pharmacology & therapeutics, 2017 - Elsevier
Obesity is a global epidemic that contributes to a number of health complications including
cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders …

Growth hormone and insulin-like growth factor 1 regulation of nonalcoholic fatty liver disease

LE Dichtel, J Cordoba-Chacon… - The Journal of Clinical …, 2022 - academic.oup.com
Patients with obesity have a high prevalence of nonalcoholic fatty liver disease (NAFLD),
representing a spectrum of simple steatosis to nonalcoholic steatohepatitis (NASH), without …

Sex differences in body composition and association with cardiometabolic risk

M Schorr, LE Dichtel, AV Gerweck, RD Valera… - Biology of sex …, 2018 - Springer
Background Body composition differs between men and women, with women having
proportionally more fat mass and men more muscle mass. Although men and women are …

American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of growth hormone deficiency in adults and …

KCJ Yuen, BMK Biller, S Radovick, JD Carmichael… - Endocrine Practice, 2019 - Elsevier
Objective: The development of these guidelines is sponsored by the American Association
of Clinical Endocrinologists (AACE) Board of Directors and American College of …

Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF‐1 in obese women

MA Bredella, M Torriani, RH Ghomi, BJ Thomas… - …, 2011 - Wiley Online Library
Recent studies have demonstrated an important physiologic link between bone and fat.
Bone and fat cells arise from the same mesenchymal precursor cell within bone marrow …

The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations

DE Berryman, CAM Glad, EO List… - Nature Reviews …, 2013 - nature.com
Obesity has become one of the most common medical problems in developed countries,
and this disorder is associated with high incidences of hypertension, dyslipidaemia …

The GH/IGF-1 axis is associated with intrahepatic lipid content and hepatocellular damage in overweight/obesity

LE Dichtel, KE Corey, MS Haines… - The Journal of …, 2022 - academic.oup.com
Context Obesity is a state of relative growth hormone (GH) deficiency, and GH has been
identified as a candidate disease-modifying target in nonalcoholic fatty liver disease …

Determinants of bone mineral density in obese premenopausal women

MA Bredella, M Torriani, RH Ghomi, BJ Thomas… - Bone, 2011 - Elsevier
Despite being a risk factor for cardiovascular disease and diabetes mellitus, obesity has
been thought to protect against osteoporosis. However, recent studies have demonstrated a …

Ectopic and serum lipid levels are positively associated with bone marrow fat in obesity

MA Bredella, CM Gill, AV Gerweck, MG Landa… - Radiology, 2013 - pubs.rsna.org
Purpose To investigate the associations between ectopic and serum lipid levels and bone
marrow fat, as a marker of stem cell differentiation, in young obese men and women, with the …

Marrow fat composition in anorexia nervosa

MA Bredella, PK Fazeli, SM Daley, KK Miller, CJ Rosen… - Bone, 2014 - Elsevier
Purpose Women with anorexia nervosa (AN) have increased marrow fat despite severe
depletion of body fat. Recent studies have suggested that marrow fat composition may serve …