The 21st century is challenging for human beings. Increased population growth, population
aging, generation of new infectious agents, and natural disasters are some threatening …

The search for a clinically affordable substitute of human blood for transfusion is still an
unmet need of modern society. More than 50 years of research on acellular hemoglobin …

Hemoglobin (Hb) is a promiscuous protein that not only transports oxygen, but also
catalyzes several biotransformations. A novel in vitro catalytic activity of Hb is described …

The widespread adoption of an agricultural circular economy requires the recovery of
resources such as water, organic matter, and nutrients from livestock manure and sanitation …

We crosslink hemoglobin (Hb), superoxide dismutase (SOD), catalase (CAT), and carbonic
anhydrase (CA) to form a soluble polyHb-SOD-CAT-CA nanobiotechnological complex. The …

Covalent labeling of therapeutic drugs and proteins with polyethylene glycol (PEGylation) is
an important modification for improving stability, solubility and half-life. PEGylation alters …

The clinical evaluation of stabilized tetrameric hemoglobin as alternatives to red cells
revealed that the materials caused significant increases in blood pressure and related …

Chemical cross-linking of human adult hemoglobin (Hb) prevents dissociation of the
tetrameric (αβ) 2 protein into its constituent non-functional αβ dimers when present outside …

Water-soluble materials that can bind, sense, and deliver oxygen are important for several
applications. These include catalysis, environmental sensors, smart packaging, agriculture …

Why is this important? Under normal circumstances, donor blood is the best replacement for
blood. However, there are exceptions:• During natural epidemics (eg, HIV, Ebola, etc.) or …