Babesiosis is an emerging tick-borne disease caused by apicomplexan parasites of the
genus Babesia. With its increasing incidence worldwide and the risk of human-to-human …

Rapid emergence of resistance to atovaquone, which targets electron transport in the
malaria parasite mitochondrion, relegated its use to prophylaxis and even cast a shadow …

Drug resistance compromises control of malaria. Here, we show that resistance to a
commonly used antimalarial medication, atovaquone, is apparently unable to spread …

We report the discovery of marinoquinoline (3 H-pyrrolo [2, 3-c] quinoline) derivatives as
new chemotypes with antiplasmodial activity. We evaluated their inhibitory activities against …

Antimalarial combination therapies play a crucial role in preventing the emergence of drug-
resistant Plasmodium parasites. Although artemisinin-based combination therapies (ACTs) …

Plasmodium parasites have a complex life cycle that includes development in the human
host as well as the Anopheles vector. Successful transmission of the parasite between its …

Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists
across lifetimes, can progressively damage sight, and is currently incurable. New, curative …

An effective strategy to control blood-borne diseases and prevent outbreak recrudescence
involves targeting conserved metabolic processes that are essential for pathogen viability …

The endochin-like quinolone (ELQ) compound class may yield effective, safe treatments for
a range of important human and animal afflictions. However, to access the public health …

Toxoplasmosis is an infectious disease with paramount impact worldwide, affecting many
vulnerable populations and representing a significant matter of concern. Current therapies …