Macropinocytosis is defined as an actin-dependent but coat-and dynamin-independent
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …

c‐Abl is a non‐receptor tyrosine kinase which is localized both in the nucleus and
cytoplasm, and is involved in the regulation of cell growth, survival and morphogenesis …

Studies of cellular and tissue dynamics benefit greatly from tools that can control protein
activity with specificity and precise timing in living systems. Here we describe an approach to …

PDGF-dependent hepatic stellate cell (HSC) recruitment is an essential step in liver fibrosis
and the sinusoidal vascular changes that accompany this process. However, the …

To elucidate the mechanisms involved in early events in Chlamydia trachomatis infection,
we conducted a large scale unbiased RNA interference screen in Drosophila melanogaster …

Cells construct a number of plasma membrane structures to meet a range of physiological
demands. Driven by juxtamembrane actin machinery, these actin-based membrane …

Receptor tyrosine kinases (RTK) are an important family of growth factor and hormone
receptors that regulate many aspects of cellular physiology. Ligand binding by RTKs at the …

Internalization and subsequent trafficking of receptor tyrosine kinases (RTKs) play an
important role in the modulation of growth factor–stimulated signaling events that affect …

Fluorescent biosensors for living cells currently require laborious optimization and a unique
design for each target. They are limited by the availability of naturally occurring ligands with …

The vitreous contains a plethora of growth factors that are strongly implicated in the
formation of fibroproliferative diseases such as proliferative vitreoretinopathy. Although …