Recent advances in dextran-based drug delivery systems: From fabrication strategies to applications

Q Hu, Y Lu, Y Luo - Carbohydrate polymers, 2021 - Elsevier
As a natural polysaccharide, dextran and its derivatives have gained great attention in the
development of delivery systems for pharmaceutical and medical applications. In recent …

Tumor-associated macrophage subsets: shaping polarization and targeting

Q Zhang, M Sioud - International journal of molecular sciences, 2023 - mdpi.com
The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and
metastasis. Among the innate immune cells recruited to the tumor site, macrophages are the …

In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles

H Arami, A Khandhar, D Liggitt… - Chemical Society …, 2015 - pubs.rsc.org
Iron oxide nanoparticles (IONPs) have been extensively used during the last two decades,
either as effective bio-imaging contrast agents or as carriers of biomolecules such as drugs …

New modalities for challenging targets in drug discovery

E Valeur, SM Guéret, H Adihou… - Angewandte Chemie …, 2017 - Wiley Online Library
Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …

Tumor penetrating peptides for improved drug delivery

E Ruoslahti - Advanced drug delivery reviews, 2017 - Elsevier
In vivo screening of phage libraries in tumor-bearing mice has been used to identify
peptides that direct phage homing to a tumor. The power of in vivo phage screening is …

Peptides as targeting elements and tissue penetration devices for nanoparticles

E Ruoslahti - Advanced materials, 2012 - Wiley Online Library
The use of nanoparticles in medicine (nanomedicine) has recently become an intensely
studied field. Nanoparticles carrying drugs and imaging agents have already reached the …

Circular RNAs as therapeutic agents and targets

LM Holdt, A Kohlmaier, D Teupser - Frontiers in physiology, 2018 - frontiersin.org
It has recently been reported that thousands of covalently linked circular RNAs (circRNAs)
are expressed from human genomes. circRNAs emerge during RNA splicing. circRNAs are …

Targeted contrast agents for magnetic resonance molecular imaging of cancer

ZR Lu, V Laney, Y Li - Accounts of chemical research, 2022 - ACS Publications
Conspectus Magnetic resonance imaging (MRI) is a clinical imaging modality that provides
high-resolution images of soft tissues, including cancerous lesions. Stable gadolinium (III) …

[HTML][HTML] Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches

J Bejarano, M Navarro-Marquez, F Morales-Zavala… - Theranostics, 2018 - ncbi.nlm.nih.gov
Cardiovascular diseases are the leading cause of death worldwide. Despite preventive
efforts, early detection of atherosclerosis, the common pathophysiological mechanism …

Combinatorial peptide libraries: mining for cell-binding peptides

BP Gray, KC Brown - Chemical reviews, 2014 - ACS Publications
The surface of a cell represents a collection of macromolecules, which provides the cell with
a unique cellular landscape specific to the type and state of the cell. Ligands that …