Key Points Genetics of Chronic Kidney Disease Genetic causes of chronic kidney disease
(CKD) are not uncommon. Patients with CKD should be referred for genetic consultation and …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

Previous studies have suggested that living kidney donors maintain long-term renal function
and experience no increase in cardiovascular or all-cause mortality. However, most …

Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate
(eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to …

Rare autosomal dominant tubulointerstitial kidney disease is caused by mutations in the
genes encoding uromodulin (UMOD), hepatocyte nuclear factor-1β (HNF1B), renin (REN) …

Epidemiological studies have raised awareness of the problem of undiagnosed chronic
kidney disease (CKD) and suggest that early identification and treatment will reduce the …

Background A main challenge for targeting chronic kidney disease (CKD) is the
heterogeneity of its causes, co-morbidities and outcomes. Patients under nephrological care …

Diabetic kidney disease remains a major microvascular complication of diabetes and the
most common cause of chronic kidney failure requiring dialysis in the United States. Medical …

Several genes that predispose to type 2 diabetes have recently been identified. In addition
to the recognized and powerful effects of environmental factors, there is abundant evidence …

Two recent matched cohort studies from the USA and Norway published in 2014 have
raised some concerns related to the long-term safety of kidney living donation. Further …