Biomedical and biotechnological applications of PEG-and PM-modified proteins

Y Inada, M Furukawa, H Sasaki, Y Kodera… - Trends in …, 1995 - cell.com
Chemical modification of proteins and other bioactive molecules with polyethylene glycol
(PEG) or its derivatives (PM) can be used to tailor molecular properties to particular …

Pegylation of proteins and bioactive substances for medical and technical applications

Y Kodera, A Matsushima, M Hiroto, H Nishimura… - Progress in Polymer …, 1998 - Elsevier
In the late 1950s, the chemical modification of proteins became commonplace and
techniques were developed to facilitate the analysis of the structure–function relationships in …

Bioconjugates of proteins and polyethylene glycol: potent tools in biotechnological processes

A Matsushima, Y Kodera, M Hiroto, H Nishimura… - Journal of Molecular …, 1996 - Elsevier
Chemical modification of enzymes and other bioactive molecules with polyethylene glycol
derivatives, activated PEG and PM, can eliminate some of the drawbacks of the …

Polyethylene glycol (PEG)-protein conjugates: Application to biomedical and biotechnological processes

Y Inada, A Matsuswma, Y Kodera… - Journal of Bioactive …, 1990 - journals.sagepub.com
P ral macromolecules to the surface of the protein molecule. In some cases, this
manipulation of protein modification with polymers can elimi-nate some drawbacks of native …

Acylation of amino functions of proteins with monomethoxypoly (ethylene glycol)-N-succinimide carbonate

M Nijs, M Gelbcke, M Azarkan, J Brygier… - Applied biochemistry …, 1994 - Springer
Abstract Monomethoxypoly (ethylene glycol)-N-succinimide carbonate (SC-PEG) was used
to prepare PEG-lysozyme, PEG-papaya proteinase III, PEG-catalase, and PEG …

Ester and Peptide Synthesis by Proteases in Organic Solvents

H KISE - Journal of Synthetic Organic Chemistry, Japan, 1991 - jstage.jst.go.jp
The interest in the synthetic reactions by enzymes in organic solvents is growing rapidly.
There are many advantages in employing enzymes in organic solvents, such as the …

2.2 Enzyme Modification with Synthetic Polymers

Y Inada - Synthesis of Biocomposite Materials, 2018 - taylorfrancis.com
This chapter focuses on work of proteins conjugated with synthetic macromolecule,
polyethylene glycol (PEG), and their potential medical and biotechnological processes …

4.1 Grafting of Enzymes with Synthetic Polymers for use in Organic Solvents

H Hideo - Synthesis of biocomposite materials, 2018 - taylorfrancis.com
This chapter describes the chemical or physical modifications of enzymes as the most
promising method for stabilization and activation of enzymes in organic solvents. It focuses …

Polyethylene glycol-modified enzymes in hydrophobic media

A Matsushima, Y Kodera, M Hiroto, H Nishimura… - … in Nonaqueous Solvents …, 2001 - Springer
Chemical modification of proteins with polyethylene glycol (PEG), a nontoxic,
nonimmunogenic, and amphipathic polymer, has been extensively studied for the purpose …

Investigations on enzyme-catalyzed peptide synthesis

JM Ricca - 1990 - wrap.warwick.ac.uk
Enzymes have been found to be catalytically active in organic solvents. Chymotrypsin was
used to synthesize a wide range of peptides when suspended in organic solvents. This …