The saccharopine pathway (SACPATH) involves the conversion of lysine into α-
aminoadipate by three enzymatic reactions catalyzed by the bifunctional enzyme lysine …

Crop biofortification is pivotal in preventing malnutrition, with lysine considered the main
limiting essential amino acid (EAA) required to maintain human health. Lysine deficiency is …

Gasdermin D (GSDMD) is a critical mediator of pyroptosis, which consists of a N-terminal
pore-forming domain and a C-terminal autoinhibitory domain. Its cytolytic activity is …

Starvation disturbance due to nutrient limitation is a common problem in bioreactors.
However, an understanding of how microbial systems respond to starvation remains in its …

Rationale: Renin-expressing cells are myoendocrine cells crucial for survival. They have
been postulated to possess a pressure-sensing mechanism, a baroreceptor, which can …

Domestication and artificial selection during production-oriented breeding have greatly
shaped the level of genomic variability in sheep. However, the genetic variation associated …

Climate change affects the duration and intensity of heat waves during summer months and
jeopardizes animal health and welfare. High ambient temperatures cause heat stress in …

The epidermal growth factor receptor (EGFR) plays important roles in multiple cellular
events, including growth, differentiation, and motility. A major mechanism of downregulating …

The gene encoding aldehyde dehydrogenase 7 family member A1 (ALDH7A1) has been
associated with the development and prognosis in multiple cancers; however, the role of …

Uncontrolled mitosis is one of the most important features of cancer, and mitotic kinases are
thought to be ideal targets for anticancer therapeutics. However, despite numerous clinical …