Deep learning to catalyze inverse molecular design

AS Alshehri, F You - Chemical Engineering Journal, 2022 - Elsevier
The discovery of superior molecular solutions through computational methods is critical for
innovative technologies and their role in addressing pressing resources, health, and …

Evaluation of input data modality choices on functional gene embeddings

F Brechtmann, T Bechtler, S Londhe… - NAR Genomics and …, 2023 - academic.oup.com
Functional gene embeddings, numerical vectors capturing gene function, provide a
promising way to integrate functional gene information into machine learning models. These …

Embeddings of genomic region sets capture rich biological associations in lower dimensions

E Gharavi, A Gu, G Zheng, JP Smith, HJ Cho… - …, 2021 - academic.oup.com
Motivation Genomic region sets summarize functional genomics data and define locations of
interest in the genome such as regulatory regions or transcription factor binding sites. The …

Improved delineation of colorectal cancer molecular subtypes and functional profiles with a 62-gene panel

D Bhukdee, P Nuwongsri, N Israsena… - Molecular Cancer …, 2023 - AACR
Since its establishment in 2015, the transcriptomics-based consensus molecular subtype
(CMS) classification has unified our understanding of colorectal cancer. Each of the four …

Deep Learning for Molecular Design: Models, Frameworks, and Applications

ASA Alshehri - 2024 - search.proquest.com
The vast and complex landscape of chemical space has traditionally been explored through
a combination of experimentation and knowledge-based computational approaches …

Baseline Acute Myeloid Leukemia Prognosis Models using Transcriptomic and Clinical Profiles by Studying the Impacts of Dimensionality Reductions and Gene …

L Sauvé, J Hébert, G Sauvageau, S Lemieux - bioRxiv, 2022 - biorxiv.org
Gene marker extraction to evaluate risk in cancer can refine the diagnosis process and lead
to adapted therapies and better survival. These survival analyses can be done through …

[PDF][PDF] Erfaneh Gharavi1, 6, Aaron Gu1, 5, Guangtao Zheng5, Jason P. Smith1, 4, Aidong Zhang5, Donald E. Brown6, and

NC Sheffield - academia.edu
Motivation: Genomic region sets summarize functional genomics data and define locations
of interest in the genome such as regulatory regions or transcription factor binding sites. The …