The liver is the largest internal organ in the human body with largest mass of glandular
tissue. Modeling the liver has been challenging due to its variety of major functions …

Noncoding genetic variation drives phenotypic diversity, but underlying mechanisms and
affected cell types are incompletely understood. Here, investigation of effects of natural …

Alcohol‐associated liver disease (ALD) is a major cause of alcohol‐related mortality. Sex
differences in sensitivity to ALD are well described, but these are often disregarded in …

Background Mouse models of alcohol‐associated liver disease vary greatly in their ease of
implementation and the pathology they produce. Effects range from steatosis and mild …

Alcohol‐associated liver disease is a major cause of alcohol‐related mortality. However, the
mechanisms underlying disease progression are not fully understood. Recently we found …

BACKGROUND: During the neonatal stage, the cardiomyocyte undergoes a constellation of
molecular, cytoarchitectural, and functional changes known collectively as cardiomyocyte …

Background & Aims Alcohol-associated liver disease (ALD) comprises a spectrum of
disorders including steatosis, steatohepatitis, fibrosis, and cirrhosis. We aimed to study the …

Macrophage-derived extracellular vesicles (EVs) play key roles in intercellular
communication. Within the liver, they have been linked to several inflammatory diseases …

Conclusions: In this ALD model, KCs are anti-inflammatory and are critical for maintenance
of hepatocyte differentiation. IMs are largely pro-inflammatory and contribute more to liver …

Here, we present a protocol for isolating human hepatocytes and neural progenitor cells
from normal and nonalcoholic steatohepatitis livers. We describe steps for perfusion for …