The bone and bone marrow are among the most frequent sites of cancer metastasis. It is
estimated that 350,000 patients die with bone metastases annually in the United States. The …

Soft tissue sarcomas (STSs) are an uncommon group of solid tumors that can arise
throughout the human lifespan. Despite their commonality as non-bony cancers that develop …

Rhabdomyosarcoma is a soft tissue sarcoma arising from cells of a mesenchymal or skeletal
muscle lineage. Alveolar rhabdomyosarcoma (ARMS) is more aggressive than the more …

Background The chemokine and bone marrow-homing receptor CXCR4 is implicated in
metastases of various cancers. This study was conducted to analyze the association of …

Chemokines, originally discovered as mediators of directional migration of immune cells to
sites of inflammation and injury, have a function beyond their role in leukocyte chemotaxis …

Rhabdomyosarcoma is the most frequent soft tissue sarcoma in children and adolescents,
with a high rate of relapse that dramatically affects the clinical outcome. Multiagent …

Ewing sarcoma is the second most common bone cancer in pediatric patients. Although the
primary cause of death in Ewing sarcoma is metastasis, the mechanism underlying tumor …

The bone marrow constitutes an unique microenvironment for cancer cells in three specific
aspects. First, the bone marrow actively recruits circulating tumor cells where they find a …

Purpose: The CXC chemokine receptor-4 (CXCR4)/stromal-derived factor-1 and c-
Met/hepatocyte growth factor axes promote the metastatic potential of rhabdomyosarcoma …

Sarcomas are a heterogeneous group of tumors with specific molecular characteristics and
currently classified on the basis of their tissue of origin and histologic appearance. Except for …