Neuropathic pain after nerve injury is severe and intractable, and current drugs and nondrug
therapies offer substantial pain relief to no more than half of affected patients. The present …

Studies in Natural Products Chemistry, Volume 79 covers the synthesis, testing and
recording of the medicinal properties of natural products, providing cutting-edge accounts of …

Benfotiamine has shown therapeutic efficacy in the treatment of painful diabetic neuropathy
in human beings. However, so far there is no evidence about the efficacy of this drug in …

Background The effects induced by thiamine and riboflavin, isolated or in association with
corticosteroids, in models of chronic inflammation are not known. Thus, we evaluated the …

Thiamin (vitamin B1) is a precursor of thiamin diphosphate (ThDP), which is a known
coenzyme of central metabolism. However, data on the noncoenzyme action of thiamin …

Abstract Treatment of neuropathic pain is an area of largely unmet medical need. Therefore,
this pain may require the development of novel drug entities. In the search for alternatives, B …

Background B vitamins have been demonstrated to be effective in treating chronic pain due
to peripheral nerve injury. We investigated whether B vitamins could alleviate neuropathic …

Aim In this study, the pharmacological interactions between a Rhodiola rosea ethanol
extract and B-vitamins such as thiamine (B 1), riboflavine (B 2), pyridoxine (B 6) …

In tissue or nerve injury, proinflammatory mediators are released that can modulate a variety
of ion channels found in nociceptors. The changes in channel activity, which primarily occurs …

There is evidence that B vitamins produce antinociception in animals. However, potentiation
of NSAID‐induced antinociception by B vitamins is unclear. The current study was designed …