Sepsis remains a major cause of morbidity and mortality worldwide, with increased burden
in low-and middle-resource settings. The role of the inflammatory response in the …

Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

BACKGROUND: In 2004, a new biomarker sCD14-subtypes (presepsin) was found and its
value was shown in the diagnosis and evaluation of sepsis. This article is a brief overview of …

Since the definition of systemic inflammatory response syndrome/sepsis was originally
proposed, a large amount of new information has been generated showing a much more …

The aim of the present study was to investigate which biomarker/s reliably assess severity
and mortality early in the sepsis process. In 47 critically-ill patients within the 24h of septic …

The pathogenesis of sepsis involves complex interaction between the host and the infecting
microorganism. Bacterial recognition and signaling are essential functions of the cells of …

The identification of the bacterial endotoxin receptors for innate immunity, most notably
TLR4 (Toll-like receptor 4), has sparked great interest in therapeutic manipulation of the …

Sepsis, a critical condition marked by systemic inflammation, profoundly impacts both innate
and adaptive immunity, often resulting in lymphopenia. This immune alteration can spare …

Purpose Reliable biomarkers for predicting subsequent sepsis among patients with
suspected acute infection are lacking. In patients presenting to emergency departments …

Inflammasome signalling induces the processing and secretion of interleukin (IL)-1β and IL-
18 which, coupled with pyroptosis, activate further the inflammatory response. In the present …