The von Willebrand A (VWA) domain is a well-studied domain involved in cell adhesion, in
extracellular matrix proteins, and in integrin receptors. A number of human diseases arise …

The integrins are a family of α, β heterodimeric receptors that mediate dynamic linkages
between extracellular adhesion molecules and the intracellular actin cytoskeleton. Integrins …

The interactions of cells with basement membranes are primarily mediated via the
engagement of laminins by a group of integrin family proteins, including integrins α3β1 …

To investigate the mechanisms by which adhesions form and disperse in migrating cells, we
expressed α5 integrin, α-actinin, and paxillin as green fluorescent protein (GFP) fusions. All …

Integrins are a structurally elaborate family of adhesion molecules that transmit signals bi-
directionally across the plasma membrane by undergoing large-scale structural …

Integrins are main cell adhesion receptors serving as linker attaching cells to extracellular
matrix (ECM) and bidirectional hubs transmitting biochemical and mechanical signals …

Eight integrin α-β heterodimers recognize ligands with an Arg-Gly-Asp (RGD) motif.
However, the structural mechanism by which integrins differentiate among extracellular …

Infection by field strains of Foot-and-mouth disease virus (FMDV) is initiated by binding to
certain species of arginine-glycine-aspartic acid (RGD)-dependent integrin including αvβ3 …

The causative agent of foot-and-mouth disease was first identified as a virus by Loeffler and
Frosch (1897)(see Brown, this volume), but visualisation of its general morphology was not …

ADAMs (adisintegrinand metalloproteases) mediate several important processes (eg tumor
necrosis factor-α release, fertilization, and myoblast fusion). The ADAM disintegrin domains …