Nonalcoholic fatty liver disease (NAFLD), a series of liver metabolic disorders manifested by
lipid accumulation within hepatocytes, has become the primary cause of chronic liver …

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease that is becoming
increasingly prevalent, and it ranges from simple steatosis to cirrhosis. However, there is still …

Hepatic lipogenesis is normally tightly regulated but is aberrantly elevated in obesity.
Fibroblast Growth Factor-15/19 (mouse FGF15, human FGF19) are bile acid-induced late …

The nuclear receptors farnesoid X receptor (FXR; NR1H4) and small heterodimer partner
(SHP; NR0B2) play crucial roles in bile acid homeostasis. Global double knockout of FXR …

Background Mitochondrial aldehyde dehydrogenase (ALDH2) displays some promise in the
protection against cardiovascular diseases although its role in diabetes has not been …

Bile acid‐CoA: amino acid N‐acyltransferase (BAAT) catalyzes bile acid conjugation, the
last step in bile acid synthesis. BAAT gene mutation in humans results in hypercholanemia …

Liver receptor homolog 1 (LRH-1), an established regulator of cholesterol and bile acid
homeostasis, has recently emerged as a potential drug target for liver disease. Although …

Mice deficient in small heterodimer partner (SHP) are protected from diet‐induced hepatic
steatosis resulting from increased fatty acid oxidation and decreased lipogenesis. The …

The accumulation of bile acids in the liver leads to the development of cholestasis and
hepatocyte injury. Nuclear receptors control the synthesis and transport of bile acids in the …

Nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner (SHP) are
important regulators of bile acid, lipid, and glucose homeostasis. Here, we show that global …