Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …

In this overview, we discuss the discovery and development of topiramate (TPM) as an
anticonvulsant, including notable aspects of its chemical, biologic, and pharmacokinetic …

Many distinct signaling pathways allow the cell to receive, process, and respond to
information. Often, components of different pathways interact, resulting in signaling …

Importance Synaptic loss is an early pathologic substrate of Alzheimer disease (AD).
Neurogranin is a postsynaptic neuronal protein that has demonstrated utility as a …

Two distinct forms of long-term depression (LTD), one dependent on the activation of NMDA
receptors (NMDARs) and the other dependent on the activation of metabotropic glutamate …

Prolonged changes in synaptic strength, such as those that occur in LTP and LTD, are
thought to contribute to learning and memory processes. These complex phenomena occur …

Ca 2+/CaM-dependent protein kinase II (CaM-KII) can phosphorylate and potentiate
responses of α-amino3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptors …

Whole-cell recordings from optic tectal neurons in Xenopus tadpoles were used to study the
maturation of a glutamatergic synapse. The first glutamatergic transmission is mediated only …

Incorporation of GluR1-containing AMPA receptors into synapses is essential to several
forms of neural plasticity, including long-term potentiation (LTP). Numerous signaling …

The pathophysiological link between type 2 diabetes mellitus (T2DM) and Alzheimer's
disease (AD) has been suggested in several reports. Few findings suggest that T2DM has …