Copper-containing enzymes perform fundamental functions by activating dioxygen (O 2) and
therefore allowing chemical energy-transfer for aerobic metabolism. The copper …

Traumatic brain injury (TBI) is a leading cause of death and disability in the United States.
Despite more than 30 years of research, no pharmacological agents have been identified …

For reasons that remain insufficiently understood, the brain requires among the highest
levels of metals in the body for normal function. The traditional paradigm for this organ and …

Otopetrin proteins (OTOPs) form proton-selective ion channels that are expressed in diverse
cell types where they mediate detection of acids or regulation of pH. In vertebrates there are …

Cav1. 3 voltage-gated L-type calcium channels (LTCCs) are involved in cardiac
pacemaking, hearing and hormone secretion, but are also expressed postsynaptically in …

Background: Researchers have gained substantial insight into mechanisms of synaptic
transmission, hyperexcitability, excitotoxicity and neurodegeneration within the last decades …

Ischemic stroke is a leading cause of long lasting disability in humans and oxidative stress
an important underlying cause. The present study aims to determine the effect of short term …

Voltage-gated calcium channels (VGCCs) represent a key link between electrical signals
and non-electrical processes, such as contraction, secretion and transcription. Evolved to …

Members of the two-pore domain K+ channel (K 2P) family are increasingly recognized as
being potential targets for therapeutic drugs and could play a role in the diagnosis and …

CaV2. 3 channels are subthreshold voltage-gated calcium channels that play crucial roles in
neurotransmitter release and regulation of membrane excitability, yet modulation of these …