Fibroblasts are activated to repair the heart following injury. Fibroblast activation in the
mammalian heart leads to a permanent fibrotic scar that impairs cardiac function. In other …

Several cellular processes depend on networks of proteins assembled at specific sites near
the plasma membrane. Scaffold proteins assemble these networks by recruiting relevant …

While the axolotl's ability to completely regenerate amputated limbs is well known and
studied, the mechanism of axolotl bone fracture healing remains poorly understood. One …

Exhibiting extreme regenerative abilities which extend to complex organs and entire limbs,
salamanders have long served as research models for understanding the basis of vertebrate …

Salamander limb regeneration is an accurate process which gives rise exclusively to the
missing structures, irrespective of the amputation level. This suggests that cells in the stump …

The heterogeneous properties of dermal cell populations have been posited to contribute
toward fibrotic, imperfect wound healing in mammals. Here we characterize an adult …

The laboratory axolotl (Ambystoma mexicanum) is widely used in biological research.
Recent advancements in genetic and molecular toolkits are greatly accelerating the work …

Form and function of the mitotic spindle depend on motor proteins that crosslink
microtubules and move them relative to each other. Among these are kinesin-14s, such as …

The salamander Ambystoma mexicanum, commonly called “the axolotl” has a long,
illustrious history as a model organism, perhaps with one of the longest track records as a …

Upon limb amputation in salamanders, anterior and posterior connective tissue cells form
distinct signalling centres that together fuel successful regeneration. The molecular …