Bone undergoes continuous remodeling, which is homeostatically regulated by concerted
communication between bone-forming osteoblasts and bone-degrading osteoclasts …

The repair process of damaged tissue involves the coordinated activities of several cell
types in response to local and systemic signals. Following acute tissue injury, infiltrating …

Mitogen-activated protein kinases (MAPKs) are ancient signal transducers well
characterized as mediators of inflammation and neoplastic transformation. Recent work has …

Icariin has been reported to enhance bone healing and treat osteoporosis. In this study, we
examined the detail molecular mechanisms of icariin on lipopolysaccharide (LPS)-induced …

ROS are implicated in bone diseases. NADPH oxidase 4 (NOX4), a constitutively active
enzymatic source of ROS, may contribute to the development of such disorders. Therefore …

Protein tyrosine phosphatases (PTP s) represent a super‐family of enzymes that play
essential roles in normal development and physiology. In this review, we will discuss the …

Genkwanin is one of the major non-glycosylated flavonoids in many herbs with anti-
inflammatory activities. Although its anti-inflammatory activity in vivo has been reported, the …

Transgenic CBA mice expressing either the tyrosine kinase GTK (gut tyrosine kinase) or the
adaptor protein SHB (Src homology 2 protein of beta-cells) under the control of the rat …

The balance of protein phosphorylation is achieved through the actions of a family of protein
serine/threonine kinases called the mitogen-activated protein kinases (MAPKs). The …

Apoptosis might be involved in the reduction of the thyroid cell population in
physiopathological situations such as goitre involution and autoimmune deleterious …