Cytoskeletal crosstalk in cell migration

S Seetharaman, S Etienne-Manneville - Trends in cell biology, 2020 - cell.com
Cell migration is a highly dynamic process driven by the cytoskeleton, which mainly
comprises the actin microfilaments, microtubules, and intermediate filaments. During …

The tubulin code, from molecules to health and disease

ED McKenna, SL Sarbanes… - Annual Review of …, 2023 - annualreviews.org
Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They
support intracellular trafficking, cell division, cellular motility, and other essential cellular …

Microtubules tune mechanosensitive cell responses

S Seetharaman, B Vianay, V Roca, AJ Farrugia… - Nature Materials, 2022 - nature.com
Mechanotransduction is a process by which cells sense the mechanical properties of their
surrounding environment and adapt accordingly to perform cellular functions such as …

Loss of the m6A methyltransferase METTL3 in monocyte-derived macrophages ameliorates Alzheimer's disease pathology in mice

H Yin, Z Ju, M Zheng, X Zhang, W Zuo, Y Wang… - PLoS …, 2023 - journals.plos.org
Alzheimer's disease (AD) is a heterogeneous disease with complex clinicopathological
characteristics. To date, the role of m6A RNA methylation in monocyte-derived macrophages …

[HTML][HTML] Generation and regulation of microtubule network asymmetry to drive cell polarity

JCM Meiring, BI Shneyer, A Akhmanova - Current opinion in cell biology, 2020 - Elsevier
Microtubules control cell architecture by serving as a scaffold for intracellular transport,
signaling, and organelle positioning. Microtubules are intrinsically polarized, and their …

Microtubule acetylation dyshomeostasis in Parkinson's disease

P Naren, KS Samim, KP Tryphena, LK Vora… - Translational …, 2023 - Springer
The inter-neuronal communication occurring in extensively branched neuronal cells is
achieved primarily through the microtubule (MT)-mediated axonal transport system. This …

Microtubules at focal adhesions–a double-edged sword

S Seetharaman… - Journal of cell …, 2019 - journals.biologists.com
Cell adhesion to the extracellular matrix is essential for cellular processes, such as migration
and invasion. In response to cues from the microenvironment, integrin-mediated adhesions …

RAB6 and microtubules restrict protein secretion to focal adhesions

L Fourriere, A Kasri, N Gareil, S Bardin… - Journal of Cell …, 2019 - rupress.org
To ensure their homeostasis and sustain differentiated functions, cells continuously transport
diverse cargos to various cell compartments and in particular to the cell surface. Secreted …

The tubulin code in mitosis and cancer

D Lopes, H Maiato - Cells, 2020 - mdpi.com
The “tubulin code” combines different α/β-tubulin isotypes with several post-translational
modifications (PTMs) to generate microtubule diversity in cells. During cell division, specific …

Tubulin post-translational modifications: the elusive roles of acetylation

B Carmona, HS Marinho, CL Matos, S Nolasco… - Biology, 2023 - mdpi.com
Simple Summary Microtubules (MTs) are dynamic structures that compose part of the cell
cytoskeleton. They play important roles in various cellular functions, such as intracellular …